Tofacitnib Citrate

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Tofacitnib Citrate Rheumatoid arthritis Guriga Gudihiisa      

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Calaamadaha alaabta

FAAHFAAHINTA SOO SAARKA

Gundhig

Tofacitinib citrate, oo sidoo kale loo yaqaan 'CP-690550 citrate', ayaa ah ka-hortag xoog leh janus kinase 3 (JAK3), unug unug-xaddidan oo tyrosine kinase ah oo ku lug leh is-beddelka calaamadaha lagu xakameynayo badbaadada lymphocyte, kordhinta, kala-duwanaanta, iyo apoptosis. Xakameyntu waa JAK3 gaar ah oo xulasho 1000-laab ka badan qaraabada kale ee aan ahayn JAK. Ka sokow joojinta JAKS (IC50 = 1 nM), tofacitinib citrate sidoo kale wuxuu joojiyaa janus kinase 2 (JAK2) iyo janus kinase 1 (JAK1) oo leh 20- iyo 100-laab ka yar awood ahaan siday u kala horreeyaan. Si kastaba ha noqotee, daraasad dhowaan la sameeyay, isku xirnaanshaha (Ki) ee tofacitinib citrate ee JAK1, JAK2, iyo JAK3 ayaa lagu soo warramey inay yihiin 1.6 nM, 21.7 nM, iyo 6.5 nM siday u kala horreeyaan.

Tixraac

Lalitha Vijayakrishnan, R. Venkataramanan iyo Palak Gulati. Ku daweynta caabuqa janus kinase inhibitor CP-690,550. Isbeddellada sayniska dawooyinka ee 2011: 32 (1); 25-34

Xigasho Badeecad

  • 1. Panagi I, Jennings E, iyo al. "Salmonella Effector SteE waxay u badashaa Mammalian Serine / Threonine Kinase GSK3 inay noqoto Tyrosine Kinase si ay u toosiso kala qaybsanaanta Macrophage." Cell Host Microbe. 2020; 27 (1): 41-53.e6. PMID: 31862381
  • 2. McInnes IB, Byers NL, iyo al. Isbarbardhigga baricitinib, upadacitinib, iyo tofacitinib dhexdhexaadinta qawaaniinta calaamadaha cytokine ee dadka leukocyte subpopulations. Arthritis Res Ther. 2019 Agoosto 2; 21 (1): 183. PMID: 31375130
  • 3. Liu S, Verma M, iyo al. "Caabbinta isteeroydhiska ee nooca hawo-mareenka 2 unugyada qanjirka 'lymphoid' ee bukaanka qaba neefta daran: Doorka thymic stromal lymphopoietin." J Allergy Clin Immunol. 2018 Jan; 141 (1): 257-268.e6. PMID: 28433687
  • 4. Zheng, Lufeng, et al. "3" UTR ee "pseudogene CYP4Z2P" wuxuu kor u qaadaa burooyinka angiogenesis ee kansarka naasaha isagoo u shaqeeya sidii ceRNA ee CYP4Z1. " Cilmi-baarista iyo daaweynta kansarka naasaha (2015): 1-14. PMID: 25701119

Sharaxaad

Tofacitinib citrate waa afka laga heli karo JAK1 / 2/3 inhibitor leh IC50s oo ah 1, 20, iyo 112 nM, siday u kala horreeyaan. Tofacitinib citrate wuxuu leeyahay nashaadaad lidka ku ah bakteeriyada, antifungal iyo antiviral.

Kaydinta

4 ° C, ka ilaali iftiinka

* Kala-baxa: -80 ° C, 6 bilood; -20 ° C, 1 bil (iftiinka ka ilaali)

 

Qaab dhismeedka kiimikada

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SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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