Asalkii hore

Tofacitinib citrate, oo sidoo kale loo yaqaan CP-690550 citrate, waa xakameyn xooggan oo ah janus kinase 3 (JAK3), oo ah unugyada hematopoetic ee xaddidan tyrosine kinase oo ku lug leh wareejinta calaamadda nidaaminta badbaadada lymphocyte, faafinta, kala duwanaanta, iyo apoptosis.Xannibaadda ayaa gaar ah JAK3 oo leh xulashada 1000-laab in ka badan kinase qoyska kale ee aan JAK ahayn.Ka sokow joojinta JAKS (IC50 = 1 nM), tofacitinib citrate waxay sidoo kale joojisaa janus kinase 2 (JAK2) iyo janus kinase 1 (JAK1) oo leh 20- iyo 100-laab ka yar siday u kala horreeyaan.Si kastaba ha ahaatee, daraasad dhowaan la sameeyay, isku-xirnaanta (Ki) ee tofacitinib citrate ee ku wajahan JAK1, JAK2, iyo JAK3 ayaa lagu soo warramey inay yihiin 1.6 nM, 21.7 nM, iyo 6.5 nM siday u kala horreeyaan.

Tixraac

Lalitha Vijayakrishnan, R. Venkataramanan iyo Palak Gulati.Daaweynta caabuqa leh janus kinase inhibitor CP-690,550.Isbeddellada Sayniska Farmasiga 2011: 32 (1);25-34

Tixraaca Alaabta

• 1. Panagi I, Jennings E, iyo al."Salmonella Effector SteE waxay u beddeshaa Serine naasleyda/Treonine Kinase GSK3 waxayna u beddeshaa Tyrosine Kinase si ay u toosiso Makrophage Polarization."Unug Host Microbe.2020;27 (1):41–53.e6.PMID:31862381
• 2. McInnes IB, Byers NL, iyo al."Isbarbardhigga baricitinib, upadacitinib, iyo tofacitinib dhexdhexaadinta nidaaminta cytokine ee calaamadaha leukocyte-ka ee bini'aadamka."Arthritis Res Ther.2019 Agoosto 2;21(1):183.PMID:31375130
• 3. Liu S, Verma M, iyo al."Cabsiga isteeroid ee marin-haweedka nooca 2 unugyada lymphoid innate ee bukaanada qaba neefta daran: Doorka thymic stromal lymphopoietin."J Xasaasiyadda Clin Immunol.2018 Jan; 141 (1): 257-268.e6.PMID:28433687
• 4. Zheng, Lufeng, iyo al."3′ UTR ee pseudogene CYP4Z2P waxay kor u qaadaa angiogenesis-ka buro kansarka naasaha iyadoo u dhaqmaysa sida ceRNA ee CYP4Z1."Cilmi-baarista iyo daaweynta kansarka naasaha (2015): 1-14.PMID:25701119

Sharaxaada

Tofacitinib citrate waa daawada afka laga heli karo ee JAK1/2/3 oo leh IC50s ee 1, 20, iyo 112 nM, siday u kala horreeyaan.Tofacitinib citrate waxay leedahay hawlo bakteeriyada, antifungal iyo fayraska.

Kaydinta

4°C, ka ilaali iftiinka

* Ku jirta dareeraha: -80 ° C, 6 bilood;-20°C, 1 bil (ka ilaali iftiinka)

Qaab dhismeedka kiimikada

Xogta Nafleyda ee La Xidhiidha

Xogta Nafleyda ee La Xidhiidha

Xogta Nafleyda ee La Xidhiidha

Xogta Nafleyda ee La Xidhiidha

Xogta Nafleyda ee La Xidhiidha