Relugolix 737789-87-6

Sharaxaad Gaaban:

Magaca API Tilmaam Tilmaamid US DMF Midowga Yurub DMF CEP
Ribociclib CAS: 737789-87-6 Antineoplastic Guriga dhexdiisa      


Faahfaahinta Alaabta

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FAAHFAAHINTA Alaabada

Relugolix waxaa loo isticmaalaa in lagu daaweeyo kansarka qanjirka 'prostate' ee ragga.
Magacyada Brand: Orgovyx
Nooca daawada: Antineoplastic - LHRH (GnRH) Kahortagayaasha Pituitary Suppressants
Helitaanka: Warqad dhakhtar ayaa loo baahan yahay
Uurka: La tasho dhakhtarkaaga.Daawadu waxay dhib u keeni kartaa ilmaha uurka ku jira.
nuujinta: la tasho dhakhtar ka hor inta aanad isticmaalin

Relugolix waa hormoon afka laga heli karo, aan peptide gonadotropin-sii dayn ah (GnRH ama luteining hormone-sii daayo hormoonka (LHRH) antagonist, oo leh waxqabad antineoplastic iman kara.Relugolix waxay si tartan ah u xidhaa oo ay xannibtaa soo-dhoweynta GnRH ee qanjidhada hore ee pituitary, taas oo labaduba ka hortagaysa GnRH ku xidhitaanka GnRH receptor waxayna joojisaa dheecaanka iyo sii deynta hormoonnada luteining (LH) iyo hormoonka kicinta follicle (FSH).Ragga, xannibaadda dheecaanka LH waxay ka hortagtaa sii deynta testosterone ee unugyada Leydig ee xiniinyaha.Tan iyo markii testosterone loo baahan yahay si loo joogteeyo kobaca qanjirka 'prostate', hoos u dhigista heerarka testosterone ayaa laga yaabaa inay horjoogsato kororka unugyada kansarka qanjirka 'prostate'.

Relugolix waa gonadotropin-sii daynta hoormoonka (GnRH) antagonist reseptor ah oo loo isticmaalo daawaynta dhowr xaaladood oo ka jawaab celin hormoon ah.Waxaa markii ugu horreysay lagu ansixiyay Japan sanadka 2019, iyadoo hoos timaada magaca sumadda Relumina, ee loogu talagalay daawaynta astaamaha fibroids uterineine-ka, iyo dhawaanahan Mareykanka 'FDA sanadka 2020, oo hoos yimaada magaca Orgovyx, ee daaweynta kansarka qanjirka 'prostate'.Relugolix sidoo kale waxaa lagu bartay daawaynta calaamadaha endometriosis.Relugolix waa kan ugu horreeya (iyo hadda kaliya) ee afka laga maamulo GnRH antagonist ee loo oggolaaday daawaynta kansarka qanjirka 'prostate' - daawaynta la midka ah sida [degarelix] waxay u baahan tahay maamul hoosaad ah - oo sidaas darteed waxay siisaa ikhtiyaar daweyn oo ka yar bukaannada laga yaabo inay u baahdaan booqashooyin rug caafimaad. loogu talagalay maamulka xirfadlayaasha daryeelka caafimaadka.Marka laga soo tago isticmaalka qaraabada ah ee loo isticmaalo, relugolix ayaa lagu muujiyay in uu ka sarreeyo niyad-jabka heerarka testosterone marka la barbardhigo [leuprolide], daawaynta kale ee androgen-ka ee loo isticmaalo daaweynta kansarka qanjirka 'prostate'.

Relugolix waa Gonadotropin Soo-dejinta Hormoonka Soo-jiidashada Hormoonka.Habka ficilka relugolix waa sida Gonadotropin Soo-dejinta Hormoonka Soo-celinta Hormoonka, iyo Cytochrome P450 3A Inducer, iyo Cytochrome P450 2B6 Inducer, iyo Kansarka Kansarka Naasaha ee Protein Inhibitor, iyo P-Glycoprotein Inhibitor.Saamaynta jireed ee relugolix waa iyada oo la adeegsanayo hoos u dhaca dheecaanka GnRH.

Qaab dhismeedka kiimikada

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SHAHAADADA

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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