Thalidomide

Sharax Gaaban:

Magaca API Tilmaam Faahfaahinta US DMF  EU DMF  CEP
Thalidomide Daawada Oncology USP / EP      

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Calaamadaha alaabta

FAAHFAAHINTA SOO SAARKA

Gundhig

Thalidomide waxaa loo soo saaray daroogada daweynta, wakiilka difaaca jirka iyo sidoo kale waxaa lagu baarayaa daaweynta calaamadaha kansarada badan. Thalidomide wuxuu xakameynayaa E3 ubiquitin ligase, taas oo ah dhisme CRBN-DDB1-Cul4A.

Sharaxaad

Thalidomide waxaa markii hore loo dallacsiiyaa inuu yahay daawo dejiye ah, wuxuu joojiyaa cereblon (CRBN), qayb ka mid ah cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, oo leh Kd of 250 nM, waxayna leedahay astaamo difaaca jirka, anti-bararka iyo anti-angiogenic.

In Vitro

Thalidomide waxaa markii hore loo dallacsiiyaa inuu yahay daawo dejiye ah, wuxuu leeyahay astaamo difaaca jirka ah, anti-bararka iyo anti-angiogenic, wuxuuna bartilmaameedsadaa cereblon (CRBN), qayb ka mid ah cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, oo leh Kd of 250 nM [1]. Thalidomide (50μg / mL) waxay awood u siineysaa waxqabadka anti-buro ee icotinib kahortaga faafitaanka labada unug ee PC9 iyo A549, saameyntana waxay kuxirantahay apoptosis iyo unuga guuritaanka. Intaa waxaa dheer, Thalidomide iyo icotinib waxay xakameysaa waddooyinka EGFR iyo VEGF-R2 ee unugyada PC9 [3].

Thalidomide (100 mg / kg, po) wuxuu joojiyaa dhigaalka kolajka, hoos u-hagaajiya heerka muujinta mRNA ee α-SMA iyo collagen I, waxayna si weyn u yareysaa cytokines-ka pro-inflammatory ee jiirka RILF. Thalidomide waxay yareysaa RILF iyadoo loo marayo xakamaynta ROS iyo hoos u dhigista TGF-β/ Wadada Smad waxay kuxirantahay xaalada Nrf2 [2]. Thalidomide (200 mg / kg, po) oo ay weheliso icotinib waxay muujineysaa saameynta ka hortagga burooyinka ee jiir qaawan oo sita unugyada PC9, xakameynaya koritaanka burooyinka iyo kor u qaadida dhimashada burooyinka [3].

Kaydinta

Budada

-20 ° C

3 sano

4 ° C

2 sano
Kala dareeraha

-80 ° C

6 bilood

-20 ° C

1 bil

Qaab dhismeedka kiimikada

Thalidomide

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

MAAMULKA TAYO

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Soo jeedin 18 Mashaariicda Qiimaynta Joogtada Tayo ee la ansixiyay 4, iyo 6 mashaariicdii waa la ansixinayaa.

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Nidaamka maaraynta tayada caalamiga ah ee horumarsan ayaa aasaas adag u dhigay iibka.

Quality management3

Kormeerka tayada ayaa maraya wareegga nolosha oo dhan ee badeecada si loo hubiyo tayada iyo saameynta daaweynta. 

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