Kaalshiyamka Atorvastatin

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Kaalshiyamka Atorvastatin Hypercholesterolemia Guriga gudihiisa / CEP 29057 CEP 2015-034

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Kaalshiyamka 'Atorvastatin Calcium' waa ka hortag xoog leh oo HMG-CoA reductase leh qiime IC50 ah 150 nM [1].
HMG-CoA reductase waa enzyme muhiim ah ee marinka mevalonate ee soo saara kolestaroolka. HMG-CoA waa enzyme xaddidan oo xaddidan waxayna muhiim u tahay yareynta heerarka kolestaroolka dhiigga. HMG-CoA reductase waxay ku taalaa qaybta loo yaqaan 'endoplasmic reticulum' waxaana ku jira sideed xayndaab transmembrane. Kahortagayaasha HMG-CoA reductase waxay soo jiidan karaan muujiyeyaasha LDL (lipoprotein low density) muujinta beerka. Waxay u horseedaa inay kordhiso heerarka catabolism-ka ee plasma LDL isla markaana hoos u dhigto isku-darka kolestaroolka plasma oo ah go'aan muhiim u ah atherosclerosis. HMG-CoA reductase waxay door muhiim ah ka ciyaartaa isku-darka kolestaroolka. HMG-CoA waa bartilmaameedka ony ee daawooyinka kalastarolka yareeya. HMG-CoA reductase sidoo kale waa enzyme muhiim u ah horumarka. Waxqabadka HMG-CoA reductase wuxuu la xiriiraa cilladaha socdaalka unugyada jeermiska. Xakamaynta waxqabadkeeda waxay u horseedi kartaa dhiig-baxa gudaha intracerebral [1].
Atorvastatin waa HMG-CoA reductase inhibitor leh qiimaha IC50 ee 154 nM. Waxay wax ku ool u leedahay daaweynta dyslipidemias iyo hypercholesterolemia [1]. Daaweynta atorvastatin ee 40 mg waxay yareyneysaa wadarta kolestaroolka 40% 40 maalmood kadib. [1] Sidoo kale waxaa loo isticmaalaa in lagu daaweeyo bukaanka ku dhaca wadnaha ama istaroogga oo leh heerar kalastarool oo caadi ah. [2] Atorvastatin wuxuu kaloo yareeyaa cufnaanta hoose ee lipoprotein apheresis ee bukaanada isagoo soo bandhigaya muujinta LDL-receptors.
Waxaa loo shiidey dhowr dheef-shiid kiimikaad oo muhiim u ah saameynta ficilada daaweynta ee CYP3A4 (cytochrome P450 3A4). [3]
Tixraacyo:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Waxtarka muddada dheer iyo badbaadada atorvastatin ee daaweynta nooca daran ee III iyo dyslipidaemia la isku daray. Wadnaha 2002, 88 (3): 234-238.
[2] Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al. - isku-darka celceliska kolestaroolka, ee Tijaabada Natiijooyinka Wadnaha ee Anglo-Scandinavian - Lipid Hoos u Dhaca Gacmeedka (ASCOT-LLA): tijaabo la xakameeyey oo lagu kala soocay. Lancet 2003, 361 (9364): 1149-1158.
[3]. Lennernas H: Daawooyinka farmasokokinetikada ee atorvastatin. Clin Pharmacokinet 2003, 42 (13): 1141-1160.

Qaab dhismeedka kiimikada

Atorvastatin-Calcium

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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