Asalkii hore

AHU-377 hemicalcium cusbo waa hemicalcium milix ah oo ah AHU-377.Waa horjooge neprilysin ah oo leh IC50 qiimaha 5 nM [1].

AHU-377 iyo angiotensin II AT1 reseptor antagonist valsartan waxay ka kooban yihiin LCZ696 ee saamiga 1:1 molar.LCZ696 waa angiotensin receptor neprilysin inhibitor.Waxay yarayn kartaa cadaadiska dhiigga waxayna noqon kartaa daawo cusub oo loogu talagalay daawaynta wadne-gabowga.AHU-377 waa dawo-yaqaan, waxa loo rogi karaa kala-goynta enzymatic ee ethyl ester-ka oo loo beddelo qaabka firfircoon ee LBQ657.Waxaa la soo wariyay in AHU-377 (30 iyo 100 mg / kg, PO) ay keeni karto saameyn antihypertensive qaab ku-tiirsanaan ah ee jiirka DAHI-SS.Laakiin DOCA-milix-jiirka hypertensive, waxay muujinaysaa hoos u dhac daciif ah [2, 3].

Tixraacyo:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide dhexdhexaadiyeyaasha endopeptidase dhexdhexaad ah.J Med Chem.1995 May 12;38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Doorka suurtagalka ah ee valsartan + AHU377 (LCZ696) ee daaweynta wadne xanuunka.Aragtida Khabiirka Baadhitaanka Daawooyinka.2013 Agoosto;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi iyo al.Waxtarka isbarbardhigga ee AHU-377, neprilysin inhibitor awood leh, oo ku jira laba nooc oo jiir ah oo dhiig-kar ku-tiirsan.BMC Pharmacology 2011, 11 (Suppl 1):P33.

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