Bictegravir 1611493-60-7

Sharax Gaaban:

Magaca API Tilmaam Hal abuure Taariikhda Waqtiga Patent uu dhacayo (Mareykanka)
Bictegravir 1611493-60-7 Cudurka HIV-1 Sayniska Gilead Diisambar 19, 2033

Faahfaahinta alaabta

Calaamadaha alaabta

FAAHFAAHINTA SOO SAARKA

Sharaxaad

Bictegravir waa sheeko cusub, xoog leh oo ka hortag ah HIV-1 oo la midoobaya IC50 ee 7.5 nM.

In Vitro

Bictegravir (BIC) wuxuu joojiyaa dhaqdhaqaaqa wareejinta xarigga oo leh IC50 oo ah 7.5± 0.3 nM Marka loo eego joojinta dhaqdhaqaaqa wareejinta xarigga, Bictegravir waa ka hortag aad u daciif ah 3'- waxqabadka barnaamijka HIV-1 IN, oo leh IC50 oo ah 241±51 nM Bictegravir wuxuu xoojiyaa isku ururinta 2-LTR goobo ~ 5-laab laxiriira xakamaynta daawaynta jeesjeeska ah waxayna yareyneysaa xaddiga alaabooyinka isdhexgalka dhabta ah ee unugyada cudurka qaba 100 laab. Bictegravir wuxuu si xoog leh u joojiyaa ku-celinta HIV-1 ee labada unug ee MT-2 iyo MT-4 oo leh EC50s oo ah 1.5 iyo 2.4 nM, siday u kala horreeyaan. Bictegravir wuxuu soo bandhigayaa saameyn xoog leh oo fayras ah labada CD4 + T lymphocytes iyo macrophages-ka laga soosaaray monocyte, oo leh EC50s 1.5±0.3 nM iyo 6.6±4.1 nM, siday u kala horreeyaan, kuwaas oo la barbardhigi karo qiimayaasha laga helo khadadka T-cell [1].

MCE si madax banaan uma aysan xaqiijin sax ahaanshaha qaababkan. Iyagu waa tixraac keliya.

Lambarka NCT Kafaalasho Xaaladda Taariikhda billowga

Wejiga

NCT03998176 Jaamacadda Nebraska | Sayniska Gilead HIV-1-infekshin Oktoobar 9, 2019

Wejiga 4

NCT03789968 Jaamacadda Thomas Jefferson | Jaamacadda Maryland, Park Park | Jaamacadda Indiana Caafimaadka | Xarunta Isbitaalka Brooklyn | Jaamacadda Illinois ee Chicago | Jaamacadda Nova Southeastern | Jaamacadda California, San Francisco HIV + AIDS Sebtember 1, 2019
NCT04249037 Jaamacadda Colorado, Denver | Sayniska Gilead HIV + AIDS Maarso 1, 2020

Ma khuseyso

NCT04132674 Xarunta Cudurada faafa ee Vancouver Fayraska 1 ee Infekshanka Difaaca Aadanaha | Isticmaalka Daroogada Nofeembar 26, 2018

Wejiga 4

NCT04054089 Cristina Mussini | Jaamacadda Modena iyo Reggio Emilia Infekshinka HIV Sebtember 2019

Wejiga 4

NCT04155554 Azienda Ospedaliera Universitaria Senese | Jaamacadda Katooliga ee Wadnaha Xurmada leh | Ospedale Policlinico San Martino | Azienda Ospedaliera San Paolo | Ospedale Amedeo di Savoia HIV-1-infekshin Janaayo 29, 2020

Wejiga 3

NCT02275065 Sayniska Gilead Cudurka HIV-1 Oktoobar 2014

Wajiga 1

NCT03711253 Jaamacadda Koonfurta California Cudurka Fudud ee HIV Oktoobar 14, 2019

Wejiga 4

NCT02400307 Sayniska Gilead HIV Abriil 17, 2015

Wajiga 1

NCT03499483 Caafimaadka Fenway Kahortaga HIV Janaayo 24, 2019

Wejiga 4

NCT03502005 Midland Research Group, Inc. | Sayniska Gilead Fayraska Difaaca Aadanaha Maarso 1, 2018

Wejiga 4

Qaab dhismeedka kiimikada

Bictegravir-1611493-60-7

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

MAAMULKA TAYO

Quality management1

Soo jeedin 18 Mashaariicda Qiimaynta Joogtada Tayo ee la ansixiyay 4, iyo 6 mashaariicdii waa la ansixinayaa.

Quality management2

Nidaamka maaraynta tayada caalamiga ah ee horumarsan ayaa aasaas adag u dhigay iibka.

Quality management3

Kormeerka tayada ayaa maraya wareegga nolosha oo dhan ee badeecada si loo hubiyo tayada iyo saameynta daaweynta. 

Quality management4

Kooxda Xakamaynta Xirfadleyda waxay taageertaa baahiyaha tayada inta lagu jiro arjiga iyo diiwaangelinta.

MAAMULKA SOO-SAARKA

cpf5
cpf6

Khadka Ku Baakadeeya Dhalada Kuuriya Countec

cpf7
cpf8

Khadka Taakulaynta Caaga Tayada ee Taiwan CVC

cpf9
cpf10

Khadka Baakadaha ee Guddiga CAM ee Talyaaniga

cpf11

Mashiinka Isku-dhafka ah ee Jarmalka

cpf12

Japan Viswill Kiniin Baadhaha

cpf14-1

Qolka Xakamaynta DCS

WADAJIR

Iskaashiga caalamiga ah
International cooperation
Wadashaqeynta gudaha
Domestic cooperation

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