Asalkii hore

AHU-377 hemicalcium cusbo waa milix hemicalcium oo ah AHU-377. Waa horjooge neprilysin oo leh IC50 qiimaha 5 nM [1].

AHU-377 iyo angiotensin II AT1 reseptor antagonist valsartan waxay ka kooban yihiin LCZ696 ee saamiga 1:1 molar. LCZ696 waa angiotensin receptor neprilysin inhibitor. Waxay yarayn kartaa cadaadiska dhiigga waxayna noqon kartaa daawo cusub oo loogu talagalay daawaynta wadne xanuunka. AHU-377 waa dawo-yaqaan, waxa loo rogi karaa kala-goynta enzymatic ee ethyl ester-ka oo loo beddelo qaabka firfircoon ee LBQ657. Waxaa la soo wariyay in AHU-377 (30 iyo 100 mg / kg, PO) ay keeni karto saameyn antihypertensive qaab ku-tiirsanaan ah ee jiirka DAHI-SS. Laakiin DOCA-milix-jiirka hypertensive, waxay muujinaysaa hoos u dhac daciif ah [2, 3].

Tixraacyo:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide dhexdhexaadiyeyaasha endopeptidase dhexdhexaad ah. J Med Chem. 1995 May 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Doorka suurtagalka ah ee valsartan + AHU377 (LCZ696) ee daaweynta wadnaha oo aan shaqeynin. Aragtida Khabiirka Baadhitaanka Daawooyinka. 2013 Agoosto;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi iyo al. Waxtarka isbarbardhigga ee AHU-377, neprilysin inhibitor awood leh, oo ku jira laba nooc oo jiir ah oo dhiig-kar ku-tiirsan. BMC Pharmacology 2011, 11 (Suppl 1):P33.

Qaab dhismeedka kiimikada