Doxycycline Hyclate
Asalkii hore
Doxycycline hyclate waa antibiyootiko [1].
Doxycycline hyclate waa mid ka soo jeeda tetracycline waxayna leedahay hawlo ka hortagga bararka iyo antimicrobial.Doxycycline waxay joojisaa ku-noqoshada fayraska dengue gudaha vitro iyadoo hab heerkul ku xiran tahay.Qiimaha IC50 waa 52.3μM at 37°C iyo 26.7μM at 40°C.Waxay joojisaa fayraska dengue iyadoo la joojinayo NS2B-NS3 serine protease ee fayraska.60μM doxycycline waxay yaraynaysaa CPE ee unugyada caabuqa DNEV2 [1].
Doxycycline waxaa lagu ogaadaa in ay joojiso MMP.Daaweynta Doxycycline waxay yaraynaysaa heerarka MMP-8 iyo -9 waxayna joojisaa muujinta unugyada MMP-2 iyo MMP-9.Waxaa intaa dheer, daaweynta doxycycline waxay si weyn u yaraynaysaa dhacdooyinka aneurysms intracranial.Doxycycline ayaa sidoo kale lagu soo warramey inay tahay wakiilka ka-hortagga bararka ee ku salaysan xannibaadda matrix metalloproteinases.Intaa waxaa dheer, doxycycline waxay leedahay firfircooni ka hortagga duumada oo awood leh oo leh IC50 qiimaha 320nM ee 96h in vitro [2, 3].
Tixraacyo:
[1] Rothan HA, Mohamed Z.Arch Virol.2014 Abriil; 159 (4): 711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Doorka matrix metalloproteinases (MMPs) iyo MMP inhibitors on aneurysms intracranial: maqaal dib u eegis.Med J Islam jamhuuriyada Iran.2013 Nov; 27 (4): 249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro iyo in vivo waxtarka ka hortagga duumada ee tetracyclines la hagaajiyay.Kiimikada Wakiilada Kahortagga Ah.2013 Jul;57(7):3131-6.
Sharaxaada
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), antibiyootik ah, waa antibiyootiko, waa ka hortag afka ah oo firfircoon oo ballaaran metalloproteinase (MMP).
Tijaabo Caafimaad
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| NCT03115177 | Rush University Medical Center | Osteoarthritis | November 2015 | Ma khuseyso |
| NCT03618108 | Cadrock Pty. Ltd.|Xarunta cudurada dheefshiidka, Australia | Cudurka Wadnaha ee Wadnaha | Abriil 4, 2018 | Wajiga 2 |
| NCT03435952 | MD Anderson Cancer Center | BioMed Valley Discoveries, Inc|Merck Sharp & Dohme Corp. | Neoplasms Malignanti ah Goobaha | Neoplasms xun ee daloolka afka ee faruuryaha iyo pharynx| neoplasms xun ee xubnaha taranka ee ragga | Luulyo 10, 2018 | Wajiga 1 |
| NCT01867294 | Cilmi-baarista Kansarka ee Waxbarashada iyo Bulshada ee United | Machadka Qaranka ee Kansarka (NCI) | Neoplasm Malignant Sare | Dhibaatada maqaarka | Ogosto 31, 2012 | Wajiga 2 |
| NCT01677286 | Jaamacadda Boston | Amyloidosis | Luulyo 2012 | Wajiga 2 |
| NCT00511875 | Thomas Gardner|Aasaaska Cilmi-baarista Sonkorowga Dhallaanka | Cudurka macaanka | Luulyo 2008 | Wajiga 2 |
| NCT04108897 | Jaamacadda Johns Hopkins | Rosacea | Sebtember 17, 2019 | Wajiga hore 1 |
| NCT00631501 | Jaamacadda Caafimaadka ee Kaunas | Isbitaalka Jaamacadda, Linkoeping | Epicondylalgia dambe (Xusalka Tennis) | Ma khuseyso | |
| NCT02203682 | Jaamacadda Sun Yat-sen | Graves Ophthalmopathy|Cudurada Qabriga | Luulyo 2014 | Wajiga 2 |
| NCT02005653 | Golaha Hindida ee Cilmi-baarista Caafimaadka | Filarial;Caabuqa | Febraayo 2009 | Wajiga 4 |
| NCT03585140 | Centro Dermatológico Dr. Ladislao de la Pascua | Finanka vulgaris|Wax ka beddelka cuntada | Janaayo 1, 2016 | Ma khuseyso |
| NCT02147262 | Xarunta Caafimaadka ee Jaamacadda Ljubljana|Jaamacadda Ljubljana School of Medicine, Slovenia | Jaamacadda Caafimaadka Vienna | Atrophic Acrodermatitis oo daba-dheeraaday | Luulyo 2013 | Ma khuseyso |
| NCT02220751 | Jaamacadda Sao Paulo | Fundação de Amparo à Pesquisa do Estado de São Paulo | Periodontitis|Nooca 2aad ee Macaanka Mellitus | Maarso 2009 | Wajiga 3 |
| NCT01825408 | Jaamacadda North Carolina, Chapel Hill | Sinusitis | Febraayo 2013 | Wajiga 4 |
| NCT02884713 | King Faysal Specialist Hospital & Xarunta Cilmi-baarista | GASTRITIS | Juun 2013 | Ma khuseyso |
| NCT02726646 | Jaamacadda Campinas, Brazil | Pontificia Universidade Catolica de Sao Paulo | Periodontitis dabadheeraad ah | Juun 2015 | Wajiga 2 |
| NCT00883818 | Xarunta Caafimaadka ee Samsung | Kaadi-haysta firfircoonida badan | Janaayo 2007 | Wajiga 4 |
| NCT00829790 | Teva Pharmaceuticals ee Maraykanka | Caafimaad qaba | Oktoobar 2006 | Wajiga 1 |
| NCT01949233 | Jaamacadda Oxford | Isbitaalada Jaamacadda Oxford NHS Trust | Marfan Syndrome | Oktoobar 2013 | Wajiga 2 |
| NCT01518192 | Xarunta Caafimaadka ee Jaamacadda Ljubljana|Hay'adda Cilmi-baarista ee Slovenia | Erythema Migrans|Calaamadaha Cudurka Lyme Kadib | Juun 2006 | Wajiga 4 |
| NCT02845024 | Islamic Azad University, Tehran | Sonkorowga Mellitus oo leh Cudurka Periodontal | Sebtembar 2014 | Ma khuseyso |
| NCT01879930 | Isbitaalka Jaamacadda Inselspital, Berne | Xanuunka miskaha ee daba-dheeraada | November 2012 | Wajiga 4 |
| NCT00041977 | CollaGenex Pharmaceuticals | Finanka Rosacea | Juun 2002 | Wajiga 3 |
| NCT02341209 | Isbitaalka Guud ee Rochester | Unugyada T-cell Lymphoma | Mycosis Fungoides| Sezary Syndrome | Febraayo 6, 2018 | Wajiga 2 |
| NCT00002872 | Kooxda Iskaashatada Oncology ee Bari | Machadka Qaranka ee Kansarka (NCI)|Kooxda Daaweynta Kansarka Bartamaha Dhexe | Kansarka Metastatic | November 1996kii | Wajiga 3 |
| NCT03162497 | Jaamacadda Caafimaadka ee Vienna | Xanuunada Indhaha Qalalan |Xanjirka Meibomian | Janaayo 8, 2018 | Wajiga 4 |
| NCT01418742 | Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH|Clin Qiimeey GmbH | Kansarka Midabka | Ogosto 2011 | Wajiga 2 |
| NCT00980148 | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID) | Infekshinka kalamiidiya | December 2009 | Wajiga 3 |
| NCT03342456 | Isbitaalka Xiangya ee Sadexaad ee Jaamacadda Bartamaha Koonfurta|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm.Ind. Co., Ltd. | Boogaha Duodenal ee ay sababto Helicobacter Pylori | December 13, 2017 | Wajiga 4 |
| NCT04310930 | Jaamacadda Queensland | Waaxda Caafimaadka ee Dowladda Australia | Aasaaska Isbitaalka Carruurta | Cystic Fibrosis Foundation ee Melbourne|Jaamacadda James Cook, Queensland, Australia|Machadka Cilmi-baarista Carruurta Murdoch | Cudurka sambabada oo ay sabab u tahay Mycobacteria (Baaritaannada) | Maarso 2020 | Wajiga 2|Wejiga 3aad |
| NCT03709459 | Machadka Kirby|Machadka Cilmi-baarista Caafimaadka iyo Caafimaadka ee Koonfurta Australia | Jaamacadda Monash | Kahortagga STIs | December 17, 2019 |
|
| NCT04067011 | BiyoSolutions Degdeg ah | Kudka | Ogosto 12, 2019 | Wajiga 2 |
| NCT02844634 | Xarunta Xakamaynta Cudurada ee British Columbia | HIV|Waraafo | May 15, 2018 | Wajiga 4 |
| NCT00647959 | Mylan Pharmaceuticals | Caafimaad qaba | March 2006 | Wajiga 1 |
| NCT00170222 | Xarunta Caafimaadka Alkmaar | Cudurka sambabada ee joogtada ah | July 2002 | Wajiga 4 |
| NCT03075891 | Galderma | Rosacea | July 5, 2017 | Wajiga 4 |
| NCT00031499 | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID) | waraabowga | Juun 2000 | Wajiga 3 |
| NCT01205464 | Jaamacadda Linkoeping | Daal|Xanuun Radicular|Aqoon La'aan|Paresthesia|Paresis | Febraayo 2005 | Ma khuseyso |
| NCT01301586 | Hal qayb oo ka mid ah Nexgen Dermatologics, Inc. | ACNE VULGARIS | November 2010 | Wajiga 1|Wejiga 2aad |
| NCT02305940 | Imperial College London | Cudurka sambabada ee joogtada ah (COPD) | Luulyo 2014 | Wajiga 3 |
| NCT00351182 | Dong-Min Kim|Cusbitaalka Jaamacadda Chosun | xoqin Tiifowga | Sebtembar 2005 | Wajiga 3 |
| NCT03334682 | Isbitaalka Jaamacadda Nantes | Acne Vulgaris | Janaayo 31, 2018 | Wajiga 3 |
| NCT01788215 | Jaamacadda Rochester | Polycystic Ovary Syndrome (PCOS)|Xeerka caadada oo aan joogto ahayn | November 2010 | Wajiga 3 |
| NCT03076281 | Sidney Kimmel Xarunta Kansarka ee Jaamacadda Thomas Jefferson | Jaamacadda Thomas Jefferson | Larynx|LIP|Daloosha Afka|Farinx | Abriil 3, 2017 | Wajiga 2 |
| NCT00439166 | Shirkadda Sayniska Caafimaadka ee Hamilton | Cudurka Alzheimers | Febraayo 2007 | Wajiga 3 |
| NCT02463942 | Xarunta Caafimaadka ee Jaamacadda Ljubljana|Jaamacadda Ljubljana School of Medicine, Slovenia | Cudurka encephalitis-ka ee shilinta | Sebtembar 2014 | Ma khuseyso |
| NCT00803842 | Jaamacadda Waqooyi-galbeed | Kansarka Sambabada Unug Yaryar | Oktoobar 2008 | Ma khuseyso |
| NCT02086591 | Jaamacadda Rochester | Cudurka Qaangaarka Large B-Cell Lymphoma | Maarso 2014 | Wajiga 2 |
| NCT03980223 | Jaamacadda California, San Francisco |Jaamacadda Washington | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID) | Jabtada|Kalamiidiya|Siphilis | November 26, 2019 | Wajiga 4 |
| NCT00355459 | Jaamacadda Texas Southwestern Medical Center | Cudurka Indhaha Qalalan | Ogosto 2005 | Ma khuseyso |
| NCT01254799 | Cumar Mamduux Shaaban|Jaamacada Assiut | Dhiigbaxa Uterineine | Janaayo 2008 | Wajiga 3 |
| NCT01547325 | NanoSHIFT LLC|Wasaaradda Difaaca ee Maraykanka | Dhaawacyo Qalliin oo Goostay | May 2012 | Ma khuseyso |
| NCT00653380 | Par Pharmaceutical, Inc.| Anapharm | Si loo go'aamiyo isku-dheelitirka bioequivalence ee xaaladaha Soonka | Sebtembar 1999kii | Wajiga 1 |
| NCT00635609 | Warner Chilcott | Acne Vulgaris | March 2008 | Wajiga 4 |
| NCT03765931 | Institut de Recherche pour le Developpement | Qandho | Luulyo 2016 | Wajiga 4 |
| NCT01160640 | Harold Wiesenfeld | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID) | Jaamacadda Pittsburgh | Cudurka bararka miskaha | November 2010 | Wajiga 2 |
| NCT01756833 | Jaamacadda Maryland, Baltimore | Machadka Qaranka ee Gabowga (NIA) | Aneurysm | May 2013 | Wajiga 2 |
| NCT00688064 | Galderma | Finanka daran vulgaris | Ogosto 2008 | Wajiga 3 |
| NCT01320033 | Galderma | Acne Vulgaris | Maarso 29, 2011 | Wajiga 2 |
| NCT03397004 | St. Michael's Hospital, Toronto | Machadka Neurological Barrow | Jaamacadda Duke | Machadka Feinstein ee Cilmi-baarista Caafimaadka | Jaamacadda Pittsburgh | Xarunta Sayniska Caafimaadka ee Sunnybrook | Telangiectasia Hemorrhagic Hemorrhagic (HHT) | Sebtember 12, 2018 | Wajiga 2 |
| NCT01635530 | Isbitaalka Jaamacadda Turku | Lyme Neuroborreliosis | Ogosto 2012 | Wajiga 4 |
| NCT03727620 | Mohammed V Suissi University | Periodontitis gardarrada | Janaayo 6, 2014 | Wajiga 1|Wejiga 2aad |
| NCT02688738 | Machadka Rothman Orthopedics | Propionibacterium | Maarso 2015 | Ma khuseyso |
| NCT00358462 | Jaamacadda Washington | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID) | Urethritis | Janaayo 2007 | Wajiga 3 |
| NCT02864550 | Xarunta Xakamaynta Cudurada ee British Columbia | waraabowga|Infekshannada lagu kala qaado galmada | Ogosto 15, 2019 | Wajiga 4 |
| NCT01595594 | Jaamacadda Sao Paulo | Fundação de Amparo à Pesquisa do Estado de São Paulo | Cudurka Periodontal|Nooca 2aad ee Macaanka | Maarso 2010 | Wajiga 3 |
| NCT00964834 | PharmAthene, Inc.| Machadyada Caafimaadka Qaranka (NIH)|Medarex|Quintiles, Inc. | Kudka | Luulyo 2009 | Wajiga 1 |
| NCT01809444 | Jaamacadda Sun Yat-sen | Cudurrada indhaha ee Thyroid Associated | November 2012 | Wajiga 2|Wejiga 3aad |
| NCT01590082 | MD Anderson Cancer Center | Machadka Qaranka ee Caafimaadka (NIH) | Machadka Qaranka ee Kansarka (NCI) | Melanoma | November 2012 | Wajiga 1|Wejiga 2aad |
| NCT00207584 | Xarumaha Xakamaynta iyo Kahortagga Cudurrada | Mycoplasma Pneumoniae | Janaayo 1994kii | Ma khuseyso |
| NCT00775177 | Ranbaxy Laboratories Limited|Ranbaxy Inc. | Caafimaad qaba | Juun 2005 | Ma khuseyso |
| NCT03462329 | Xarunta Caafimaadka ee Jaamacadda Ljubljana | Erythema Migrans | Juun 1, 2018 | Ma khuseyso |
| NCT00000403 | Jaamacadda Indiana | Machadka Qaranka ee Arthritis iyo Musculoskeletal iyo Cudurada Maqaarka (NIAMS) | Osteoarthritis | Sebtembar 1996kii | Wajiga 3 |
| NCT03508232 | Jaamacadda Alberta | Isbitaalka Royal Alexandra | Wadnaha Wadnaha oo Kor u kaca Qaybta ST | Janaayo 6, 2020 | Wajiga 2 |
| NCT02553473 | Isbitaalka Sorlandet HF | Neuroborreliosis, Borrelia Burgdorferi | Oktoobar 2015 | Wajiga 3 |
| NCT02207556 | Kuliyadda Caafimaadka ee Wisconsin | Amyloidosis habdhiska aasaasiga ah | Oktoobar 1, 2014 | Wajiga 2 |
| NCT01783106 | Isbitaalka Jaamacadda Royal Liverpool | Ururka Qaranka ee Colitis iyo Crohn's Disease | Machadka Qaranka ee Cilmi-baarista Caafimaadka, Boqortooyada Ingiriiska | Cudurka Crohn | Febraayo 1, 2014 | Wajiga 2 |
| NCT00353743 | Isbitaalka de Clinicas de Porto Alegre | Ilmo soo rididda, Septic | May 2006 | Ma khuseyso |
| NCT01727973 | Jaamacadda Sun Yat-sen | Graves Ophthalmopathy|Cudurada Qabriga | Oktoobar 2012 | Wajiga 1|Wejiga 2aad |
| NCT00857038 | Xarunta Caafimaadka Alkmaar|Xarunta Caafimaadka Jaamacadda Leiden|Jaamacadda Amsterdam | Cudurka sambabada xanniba ee daba dheeraada | bararka| | Abriil 2009 | Wajiga 4 |
| NCT02774993 | Isbitaalka Jaamacadda Qaranka, Singapore|Csbitaalka Tan Tock Seng|Jaamacadda Qaranka, Singapore|A*Xiddiga | Qaaxada | Sebtembar 2015 | Wajiga 2 |
| NCT03474458 | IRCCS Policlinico S. Matteo | Wadnaha AL Amyloidosis | Febraayo 11, 2019 | Wajiga 2|Wejiga 3aad |
| NCT02874430 | Sidney Kimmel Xarunta Kansarka ee Jaamacadda Thomas Jefferson | Jaamacadda Thomas Jefferson | Kansarka naaska|Uterine Corpus Carcinoma | Juun 8, 2016 | Wajiga 2 |
| NCT00016835 | Jaamacadda Michigan | Machadka Qaranka ee Cilmi-baarista Ilkaha iyo Craniofacial (NIDCR) | Xanuunka Xiliga |Diabetes Mellitus, Nooca 2 | Oktoobar 17, 2001 | Wajiga 2 |
| NCT00064766 | Eunice Kennedy Shriver Machadka Qaranka ee Caafimaadka Carruurta iyo Horumarinta Aadanaha (NICHD) | Dhiig-baxa Endometrial | Cudur waqtiyeedka | Febraayo 2003 | Wajiga 4 |
| NCT00803452 | Jaamacadda Louisville | Blepharitis | Luulyo 2008 | Wajiga 4 |
| NCT01434173 | Bayer|RTI Caafimaadka Xalka | Dhaawaca Beerka ee Daroogadu keentay | Luulyo 2001 |
|
| NCT00126204 | Barnes-Jewish Hospital | Aortic Aneurysm | March 2004 | Ma khuseyso |
| NCT01917721 | Caafimaadka Hawaii Pacific | Cudurka Kawasaki|Aneurysm-ka wadnaha | Oktoobar 2013 | Wajiga 2 |
| NCT02775695 | Kuliyadda Caafimaadka ee Wisconsin | Kansarka xameetida ee la soo saari karo | Abriil 3, 2017 | Wajiga 2 |
| NCT03824340 | Isbitaalka Aljazeera | Dhalmo la'aan | Janaayo 30, 2019 | Ma khuseyso |
| NCT01847976 | Ottawa Hospital Research Institute|Canada Canadian Breast Cancer Foundation | Xanuun | Ogosto 2013 | Wajiga 2 |
| NCT02850913 | Jaamacadda Makerere | Jaamacadda Oxford | Suuxdin | Sebtembar 5, 2016 | Wajiga 2 |
| NCT00764361 | NanoSHIFT LLC | Boogaha cagta ee macaanka | Janaayo 2009 | Wajiga 2 |
| NCT02036528 | Hal qayb oo ka mid ah Royer Biomedical, Inc. | Boogaha cagaha ee macaanka | Janaayo 2014 | Wajiga 1|Wejiga 2aad |
| NCT01661985 | Maamulka gobolka Ostergotland, Iswiidhan|Machadka Serum State | Urethritis | Cervicitis | Caabuqa Mycoplasma xubinta taranka | Chlamydia Trachomatis | Febraayo 2010 | Wajiga 4 |
| NCT01380483 | Par Pharmaceutical, Inc.| Anapharm | Si loo go'aamiyo isku-dheelitirka bioequivalence ee xaaladaha Soonka | Janaayo 2000 | Wajiga 1 |
| NCT00648180 | Mylan Pharmaceuticals | Caafimaad qaba | July 2005 | Wajiga 1 |
| NCT01426269 | Galderma Laboratories, LP | Rosacea | Sebtembar 2011 | Wajiga 4 |
| NCT02753426 | Jaamacadda California, San Francisco | Cudurka kelyaha ee raaga | Wadnaha xanuunka | Abriil 2016 | Wajiga 1 |
| NCT02583282 | Machadka Waxbarashada Caafimaadka iyo Cilmi-baarista ee Postgraduate | Dhiigbax Xun | Ogosto 1, 2015 | Ma khuseyso |
| NCT02927496 | Kooxda Task Force ee Caafimaadka Caalamiga ah|United States Agency for International Development (USAID) | Lymphedema|Lymphatic Filariasis|Filariasis | Juun 19, 2018 | Wajiga 3 |
| NCT00652795 | Par Pharmaceutical, Inc.| Anapharm | Si loo go'aamiyo isku-dheelitirka bioequivalence ee xaaladaha Soonka | Luulyo 2004 | Wajiga 1 |
| NCT03956212 | Xarunta Caafimaadka ee Jaamacadda Ljubljana|Jaamacadda Ljubljana School of Medicine, Slovenia | Erythema Migrans | Juun 1, 2017 | Ma khuseyso |
| NCT00855595 | Bayer | Papulopustular Rosacea | Febraayo 2009 | Wajiga 4 |
| NCT03457636 | Cilmi-baarista maqaarka, PLLC | finanka | Maarso 19, 2018 | Wajiga 4 |
| NCT02894268 | Sir Run Run Shaw Hospital | Caabuqa Helicobacter Pylori | Febraayo 2016 | Wajiga 4 |
| NCT03465774 | MD Anderson Cancer Center | Machadka Qaranka ee Kansarka (NCI) | Dhiigbax Xun | Maarso 8, 2018 | Wajiga hore 1 |
Qaab dhismeedka kiimikada
Soo jeedin18Mashaariicda Qiimaynta Joogtada Tayada ee la ansixiyay4iyo6mashaariicda ayaa ku socda ansixinta.
Nidaamka maaraynta tayada sare ee caalamiga ah ayaa dhigay aasaas adag oo iib ah.
Kormeerka tayada wuxuu ku socdaa dhammaan wareegga nolosha ee alaabta si loo hubiyo tayada iyo saameynta daaweynta.
Kooxda Arrimaha Sharciyaynta Xirfadlayaasha waxay taageertaa shuruudaha tayada inta lagu jiro codsiga iyo diiwaangelinta.
Khadka Baakadaha ee Countec ee Kuuriya
Khadka baakadaha dhalada ee Taiwan CVC
Taliyaaniga CAM Khadka Baakadaha
Jarmal Fette Machine Compacting
Japan Viswill Tablet Detector
Qolka Xakamaynta DCS
iskaashiga caalamiga ah
iskaashiga gudaha
Halkan ku qor fariintaada oo noo soo dir
