Soosaarayaasha iyo alaab-qeybiyeyaasha China Doxycycline Hyclate

Doxycycline Hyclate

Sharaxaad Gaaban:

Magaca API	Tilmaan	Tilmaamid	US DMF	Midowga Yurub DMF	CEP
Doxycycline Hyclate	Antibiyootiga	USP/EP	13771	√

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Asalkii hore

Doxycycline hyclate waa antibiyootiko [1].

Doxycycline hyclate waa nooc ka soo jeeda tetracycline waxayna leedahay waxqabadyada ka hortagga bararka iyo antimicrobial. Doxycycline waxay joojisaa ku-noqoshada fayraska dengue gudaha vitro iyadoo hab heerkul ku xiran tahay. Qiimaha IC50 waa 52.3μM at 37°C iyo 26.7μM at 40°C. Waxay joojisaa fayraska dengue iyadoo la joojinayo NS2B-NS3 serine protease ee fayraska. 60μM doxycycline waxay yaraynaysaa CPE ee unugyada caabuqa DNEV2 [1].

Doxycycline waxaa lagu ogaadaa inuu yahay horjoogaha MMP. Daaweynta Doxycycline waxay yaraynaysaa heerarka MMP-8 iyo -9 waxayna joojisaa muujinta unugyada MMP-2 iyo MMP-9. Waxaa intaa dheer, daaweynta doxycycline waxay si weyn u yaraynaysaa dhacdooyinka aneurysms intracranial. Doxycycline ayaa sidoo kale lagu soo warramey inay tahay wakiilka ka-hortagga bararka ee ku salaysan xannibaadda matrix metalloproteinases. Intaa waxaa dheer, doxycycline waxay leedahay firfircooni ka hortagga duumada oo awood leh oo leh IC50 qiimaha 320nM ee 96h in vitro [2, 3].

Tixraacyo:
[1] Rothan HA, Mohamed Z. Arch Virol. 2014 Abriil; 159 (4): 711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Doorka matrix metalloproteinases (MMPs) iyo MMP inhibitors on aneurysms intracranial: maqaal dib u eegis ah. Med J Islam jamhuuriyada Iran. 2013 Nof;27 (4): 249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro iyo in vivo waxtarka ka hortagga duumada ee tetracyclines la hagaajiyay. Kiimikada wakiilada Ka-hortagga ah. 2013 Jul;57(7):3131-6.

Sharaxaada

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), antibiyootiko, waa antibiyootiko, waa ka hortag afka ah oo firfircoon oo ballaaran metalloproteinase (MMP).

Tijaabo Caafimaad

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NCT03618108	Cadrock Pty. Ltd.\|Xarunta cudurada dheefshiidka, Australia	Cudurka Wadnaha ee Wadnaha	Abriil 4, 2018	Wajiga 2
NCT03435952	MD Anderson Cancer Center \| BioMed Valley Discoveries, Inc\|Merck Sharp & Dohme Corp.	Neoplasms xun ee naaska\| neoplasms xun ee xubnaha dheefshiidka Goobaha\|Malignant Neoplasms ee daloolka afka ee faruuryaha iyo pharynx\| neoplasms xun ee xubnaha taranka ee ragga	Luulyo 10, 2018	Wajiga 1
NCT01867294	Cilmi-baarista Kansarka ee Waxbarashada iyo Bulshada ee United \| Machadka Qaranka ee Kansarka (NCI)	Neoplasm Malignant Sare \| Dhibaatada maqaarka	Ogosto 31, 2012	Wajiga 2
NCT01677286	Jaamacadda Boston	Amyloidosis	Luulyo 2012	Wajiga 2
NCT00511875	Thomas Gardner\|Aasaaska Cilmi-baarista Sonkorowga Dhallaanka	Cudurka macaanka	July 2008	Wajiga 2
NCT04108897	Jaamacadda Johns Hopkins	Rosacea	Sebtember 17, 2019	Wajiga hore 1
NCT00631501	Jaamacadda Caafimaadka ee Kaunas \| Isbitaalka Jaamacadda, Linkoeping	Epicondylalgia dambe (Xusalka Tennis)		Aan lagu dabaqi karin
NCT02203682	Jaamacadda Sun Yat-sen	Graves Ophthalmopathy\|Cudurada Qabriga	Luulyo 2014	Wajiga 2
NCT02005653	Golaha Hindida ee Cilmi-baarista Caafimaadka	Filarial; Caabuqa	Febraayo 2009	Wajiga 4
NCT03585140	Centro Dermatológico Dr. Ladislao de la Pascua	Finanka vulgaris\|Wax ka beddelka cuntada	Janaayo 1, 2016	Aan lagu dabaqi karin
NCT02147262	Xarunta Caafimaadka ee Jaamacadda Ljubljana\|Jaamacadda Ljubljana School of Medicine, Slovenia \| Jaamacadda Caafimaadka Vienna	Atrophic Acrodermatitis oo daba-dheeraada	Luulyo 2013	Aan lagu dabaqi karin
NCT02220751	Jaamacadda Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontitis\|Nooca 2aad ee Macaanka Mellitus	Maarso 2009	Wajiga 3
NCT01825408	Jaamacadda North Carolina, Chapel Hill	Sinusitis	Febraayo 2013	Wajiga 4
NCT02884713	King Faysal Specialist Hospital & Xarunta Cilmi-baarista	GASTRITIS	Juun 2013	Aan lagu dabaqi karin
NCT02726646	Jaamacadda Campinas, Brazil\|Pontificia Universidade Catolica de Sao Paulo	Periodontitis dabadheeraad ah	Juun 2015	Wajiga 2
NCT00883818	Xarunta Caafimaadka ee Samsung	Kaadi-haysta firfircoonida badan	Janaayo 2007	Wajiga 4
NCT00829790	Teva Pharmaceuticals ee Maraykanka	Caafimaad qaba	Oktoobar 2006	Wajiga 1
NCT01949233	Jaamacadda Oxford \| Isbitaalada Jaamacadda Oxford NHS Trust	Marfan Syndrome	Oktoobar 2013	Wajiga 2
NCT01518192	Xarunta Caafimaadka ee Jaamacadda Ljubljana\|Hay'adda Cilmi-baarista ee Slovenia	Erythema Migrans\|Calaamadaha Cudurka Lyme Kadib	Juun 2006	Wajiga 4
NCT02845024	Islamic Azad University, Tehran	Sonkorowga Mellitus oo leh Cudurka Periodontal	Sebtembar 2014	Aan lagu dabaqi karin
NCT01879930	Isbitaalka Jaamacadda Inselspital, Berne	Xanuunka miskaha ee daba-dheeraada\|Kaadi-haysta Xanuunka	November 2012	Wajiga 4
NCT00041977	CollaGenex Pharmaceuticals	Finanka Rosacea	Juun 2002	Wajiga 3
NCT02341209	Isbitaalka Guud ee Rochester	Unugyada T-cell Lymphoma \| Mycosis Fungoides\| Sezary Syndrome	Febraayo 6, 2018	Wajiga 2
NCT00002872	Kooxda Iskaashatada Oncology ee Bari \| Machadka Qaranka ee Kansarka (NCI)\|Kooxda Daaweynta Kansarka Bartamaha Dhexe	Kansarka Metastatic	November 1996kii	Wajiga 3
NCT03162497	Jaamacadda Caafimaadka ee Vienna	Xanuunada Indhaha Qalalan	Janaayo 8, 2018	Wajiga 4
NCT01418742	Gesellschaft fur Medizinische Innovation ? Hamatologie und Onkologie mbH\|Clin qiimee GmbH	Kansarka Colorectal	Ogosto 2011	Wajiga 2
NCT00980148	Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID)	Infekshanka Kalamiidiya	December 2009	Wajiga 3
NCT03342456	Isbitaalka Xiangya ee Sadexaad ee Jaamacadda Bartamaha Koonfurta\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm. Ind. Co., Ltd.	Boogaha Duodenal oo ay sababto Helicobacter Pylori	December 13, 2017	Wajiga 4
NCT04310930	Jaamacadda Queensland \| Waaxda Caafimaadka ee Dowladda Australia \| Aasaaska Isbitaalka Carruurta \| Cystic Fibrosis Foundation ee Melbourne\|Jaamacadda James Cook, Queensland, Australia\|Machadka Cilmi-baarista Carruurta Murdoch	Cudurka sambabada oo ay sabab u tahay Mycobacteria (Baaritaannada)	Maarso 2020	Wajiga 2\|Wejiga 3aad
NCT03709459	Machadka Kirby\|Machadka Cilmi-baarista Caafimaadka iyo Caafimaadka ee Koonfurta Australia \| Jaamacadda Monash	Kahortagga STIs	December 17, 2019
NCT04067011	BiyoSolutions Degdeg ah\|Maamulka Cilmi-baarista Sare ee Biomedical	Kudka	Ogosto 12, 2019	Wajiga 2
NCT02844634	Xarunta Xakamaynta Cudurada ee British Columbia	HIV\|Waraabow	May 15, 2018	Wajiga 4
NCT00647959	Mylan Pharmaceuticals	Caafimaad qaba	March 2006	Wajiga 1
NCT00170222	Xarunta Caafimaadka Alkmaar	Cudurka sambabada ee joogtada ah	July 2002	Wajiga 4
NCT03075891	Galderma	Rosacea	July 5, 2017	Wajiga 4
NCT00031499	Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID)	waraabowga	Juun 2000	Wajiga 3
NCT01205464	Jaamacadda Linkoeping	Daal\|Xanuun Radicular\|Caqli-xumo Garasho\|Paresthesia\|Paresis	Febraayo 2005	Aan lagu dabaqi karin
NCT01301586	Hal qayb oo ka mid ah Nexgen Dermatologics, Inc.	ACNE VULGARIS	November 2010	Wajiga 1\|Wejiga 2aad
NCT02305940	Imperial College London	Cudurka sambabada ee joogtada ah (COPD)	Luulyo 2014	Wajiga 3
NCT00351182	Dong-Min Kim\|Cusbitaalka Jaamacadda Chosun	xoqin Tiifowga	Sebtembar 2005	Wajiga 3
NCT03334682	Isbitaalka Jaamacadda Nantes	Acne Vulgaris	Janaayo 31, 2018	Wajiga 3
NCT01788215	Jaamacadda Rochester	Polycystic Ovarian Syndrome (PCOS)\|Xeerka caadada oo aan joogto ahayn	November 2010	Wajiga 3
NCT03076281	Sidney Kimmel Xarunta Kansarka ee Jaamacadda Thomas Jefferson \| Jaamacadda Thomas Jefferson	Larynx\|LIP\|Daloosha Afka\|Farinx	Abriil 3, 2017	Wajiga 2
NCT00439166	Shirkadda Sayniska Caafimaadka ee Hamilton	Cudurka Alzheimers	Febraayo 2007	Wajiga 3
NCT02463942	Xarunta Caafimaadka ee Jaamacadda Ljubljana\|Jaamacadda Ljubljana School of Medicine, Slovenia	Cudurka encephalitis-ka ee shilinta	Sebtembar 2014	Aan lagu dabaqi karin
NCT00803842	Jaamacadda Waqooyi-galbeed	Kansarka Sambabada Unug Yaryar	Oktoobar 2008	Aan lagu dabaqi karin
NCT02086591	Jaamacadda Rochester	Cudurka Qaangaarka Large B-Cell Lymphoma\|Lymphoma Unugyada Mantle Soo Noqnoqda\|Lymphoma, Follicular\|Aaga Marginal B-Cell Lymphoma\|Lymphoma Malignant Lymphoma	Maarso 2014	Wajiga 2
NCT03980223	Jaamacadda California, San Francisco \|Jaamacadda Washington \| Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID)	Jabtada\|Kalamiidiya\|Siphilis	November 26, 2019	Wajiga 4
NCT00355459	Jaamacadda Texas Southwestern Medical Center	Cudurka Indhaha Qalalan	Ogosto 2005	Aan lagu dabaqi karin
NCT01254799	Cumar Mamduux Shaaban\|Jaamacada Assiut	Dhiigbaxa Uterineine	Janaayo 2008	Wajiga 3
NCT01547325	NanoSHIFT LLC\|Wasaaradda Difaaca ee Maraykanka	Dhaawacyo Qalliin oo Goostay	May 2012	Aan lagu dabaqi karin
NCT00653380	Par Pharmaceutical, Inc.\| Anapharm	Si loo Go'aamiyo Isku-dheelitirnaanta Bioequivalence ee Xaaladaha Soonka	Sebtembar 1999kii	Wajiga 1
NCT00635609	Warner Chilcott	Acne Vulgaris	March 2008	Wajiga 4
NCT03765931	Institut de Recherche pour le Developpement	Qandho	Luulyo 2016	Wajiga 4
NCT01160640	Harold Wiesenfeld \| Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID) \| Jaamacadda Pittsburgh	Cudurka bararka miskaha	November 2010	Wajiga 2
NCT01756833	Jaamacadda Maryland, Baltimore \| Machadka Qaranka ee Gabowga (NIA)	Aneurysm	May 2013	Wajiga 2
NCT00688064	Galderma	Finanka daran vulgaris	Ogosto 2008	Wajiga 3
NCT01320033	Galderma	Acne Vulgaris	Maarso 29, 2011	Wajiga 2
NCT03397004	St. Michael's Hospital, Toronto \| Machadka Neurological Barrow \| Jaamacadda Duke \| Machadka Feinstein ee Cilmi-baarista Caafimaadka \| Jaamacadda Pittsburgh \| Xarunta Sayniska Caafimaadka ee Sunnybrook	Telangiectasia Hemorrhagic Hemorrhagic (HHT)	Sebtember 12, 2018	Wajiga 2
NCT01635530	Isbitaalka Jaamacadda Turku	Lyme Neuroborreliosis	Ogosto 2012	Wajiga 4
NCT03727620	Mohammed V Suissi University	Periodontitis gardarrada	Janaayo 6, 2014	Wajiga 1\|Wejiga 2aad
NCT02688738	Machadka Rothman Orthopedics	Propionibacterium	Maarso 2015	Aan lagu dabaqi karin
NCT00358462	Jaamacadda Washington \| Machadka Qaranka ee Xasaasiyadda iyo Cudurada Faafa (NIAID)	Urethritis	Janaayo 2007	Wajiga 3
NCT02864550	Xarunta Xakamaynta Cudurada ee British Columbia	waraabowga\|Infekshannada lagu kala qaado galmada	Ogosto 15, 2019	Wajiga 4
NCT01595594	Jaamacadda Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Cudurka Periodontal \| Nooca 2aad ee Macaanka	Maarso 2010	Wajiga 3
NCT00964834	PharmAthene, Inc.\| Machadyada Caafimaadka Qaranka (NIH)\|Medarex\|Quintiles, Inc.	Kudka	Luulyo 2009	Wajiga 1
NCT01809444	Jaamacadda Sun Yat-sen	Cudurrada indhaha ee Thyroid Associated	November 2012	Wajiga 2\|Wejiga 3aad
NCT01590082	MD Anderson Cancer Center \| Machadka Qaranka ee Caafimaadka (NIH) \| Machadka Qaranka ee Kansarka (NCI)	Melanoma	November 2012	Wajiga 1\|Wejiga 2aad
NCT00207584	Xarumaha Xakamaynta iyo Kahortagga Cudurrada	Mycoplasma Pneumoniae	Janaayo 1994kii	Aan lagu dabaqi karin
NCT00775177	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	Caafimaad qaba	Juun 2005	Aan lagu dabaqi karin
NCT03462329	Xarunta Caafimaadka ee Jaamacadda Ljubljana	Erythema Migrans	Juun 1, 2018	Aan lagu dabaqi karin
NCT00000403	Jaamacadda Indiana \| Machadka Qaranka ee Arthritis iyo Musculoskeletal iyo Cudurada Maqaarka (NIAMS)	Osteoarthritis	Sebtembar 1996kii	Wajiga 3
NCT03508232	Jaamacadda Alberta \| Isbitaalka Royal Alexandra	Qaybta ST ee Wadnaha Wadnaha ee Wadnaha \|	Janaayo 6, 2020	Wajiga 2
NCT02553473	Isbitaalka Sorlandet HF	Neuroborreliosis, Borrelia Burgdorferi	Oktoobar 2015	Wajiga 3
NCT02207556	Kuliyadda Caafimaadka ee Wisconsin	Amyloidosis habdhiska aasaasiga ah	Oktoobar 1, 2014	Wajiga 2
NCT01783106	Isbitaalka Jaamacadda Royal Liverpool \| Ururka Qaranka ee Colitis iyo Crohn's Disease \| Machadka Qaranka ee Cilmi-baarista Caafimaadka, Boqortooyada Ingiriiska	Cudurka Crohn	Febraayo 1, 2014	Wajiga 2
NCT00353743	Isbitaalka de Clinicas de Porto Alegre	Ilmo soo rididda, Septic	May 2006	Aan lagu dabaqi karin
NCT01727973	Jaamacadda Sun Yat-sen	Graves Ophthalmopathy\|Cudurada Qabriga	Oktoobar 2012	Wajiga 1\|Wejiga 2aad
NCT00857038	Xarunta Caafimaadka Alkmaar\|Xarunta Caafimaadka Jaamacadda Leiden\|Jaamacadda Amsterdam	Cudurka sambabada xanniba ee daba dheeraada \| bararka\|	Abriil 2009	Wajiga 4
NCT02774993	Isbitaalka Jaamacadda Qaranka, Singapore\|Csbitaalka Tan Tock Seng\|Jaamacadda Qaranka, Singapore\|A*Xiddiga	Qaaxada	Sebtembar 2015	Wajiga 2
NCT03474458	IRCCS Policlinico S. Matteo	Wadnaha AL Amyloidosis	Febraayo 11, 2019	Wajiga 2\|Wejiga 3aad
NCT02874430	Sidney Kimmel Xarunta Kansarka ee Jaamacadda Thomas Jefferson \| Jaamacadda Thomas Jefferson	Kansarka naaska\|Uterine Corpus Carcinoma	Juun 8, 2016	Wajiga 2
NCT00016835	Jaamacadda Michigan \| Machadka Qaranka ee Cilmi-baarista Ilkaha iyo Craniofacial (NIDCR)	Xanuunka Xiliga \|Diabetes Mellitus, Nooca 2	Oktoobar 17, 2001	Wajiga 2
NCT00064766	Eunice Kennedy Shriver Machadka Qaranka ee Caafimaadka Carruurta iyo Horumarinta Aadanaha (NICHD)	Dhiig-baxa Endometrial \| Cudur waqtiyeedka	Febraayo 2003	Wajiga 4
NCT00803452	Jaamacadda Louisville	Blepharitis	July 2008	Wajiga 4
NCT01434173	Bayer\|RTI Xalka Caafimaadka	Dhaawaca Beerka ee Daroogadu keentay	July 2001
NCT00126204	Barnes-Jewish Hospital	Aortic Aneurysm	March 2004	Aan lagu dabaqi karin
NCT01917721	Caafimaadka Hawaii Pacific	Cudurka Kawasaki\|Aneurysm-ka wadnaha	Oktoobar 2013	Wajiga 2
NCT02775695	Kuliyadda Caafimaadka ee Wisconsin	Kansarka xameetida ee la soo saari karo	Abriil 3, 2017	Wajiga 2
NCT03824340	Isbitaalka Aljazeera	Dhalmo la'aan	Janaayo 30, 2019	Aan lagu dabaqi karin
NCT01847976	Ottawa Hospital Research Institute\|Canadian Breast Cancer Foundation	Xanuun	Ogosto 2013	Wajiga 2
NCT02850913	Jaamacadda Makerere \| Jaamacadda Oxford	Suuxdin	Sebtembar 5, 2016	Wajiga 2
NCT00764361	NanoSHIFT LLC	Boogaha cagta ee macaanka	Janaayo 2009	Wajiga 2
NCT02036528	Hal qayb oo ka mid ah Royer Biomedical, Inc.	Boogaha cagaha ee macaanka	Janaayo 2014	Wajiga 1\|Wejiga 2aad
NCT01661985	Maamulka Gobolka Ostergotland, Iswiidhan\|Machadka Serum State	Urethritis \| Cervicitis \| Caabuqa Mycoplasma xubinta taranka \| Chlamydia Trachomatis	Febraayo 2010	Wajiga 4
NCT01380483	Par Pharmaceutical, Inc.\| Anapharm	Si loo Go'aamiyo Isku-dheelitirnaanta Bioequivalence ee Xaaladaha Soonka	Janaayo 2000	Wajiga 1
NCT00648180	Mylan Pharmaceuticals	Caafimaad qaba	July 2005	Wajiga 1
NCT01426269	Galderma Laboratories, LP	Rosacea	Sebtembar 2011	Wajiga 4
NCT02753426	Jaamacadda California, San Francisco	Cudurka kelyaha ee raaga \| Wadnaha xanuunka	Abriil 2016	Wajiga 1
NCT02583282	Machadka Waxbarashada Caafimaadka iyo Cilmi-baarista ee Postgraduate	Dhiigbax Xun	Ogosto 1, 2015	Aan lagu dabaqi karin
NCT02927496	Kooxda Task Force ee Caafimaadka Caalamiga ah\|United States Agency for International Development (USAID)	Lymphedema\|Lymphatic Filariasis\|Filariasis	Juun 19, 2018	Wajiga 3
NCT00652795	Par Pharmaceutical, Inc.\| Anapharm	Si loo Go'aamiyo Isku-dheelitirnaanta Bioequivalence ee Xaaladaha Soonka	July 2004	Wajiga 1
NCT03956212	Xarunta Caafimaadka ee Jaamacadda Ljubljana\|Jaamacadda Ljubljana School of Medicine, Slovenia	Erythema Migrans	Juun 1, 2017	Aan lagu dabaqi karin
NCT00855595	Bayer	Papulopustular Rosacea	Febraayo 2009	Wajiga 4
NCT03457636	Cilmi-baarista maqaarka, PLLC	finanka	Maarso 19, 2018	Wajiga 4
NCT02894268	Sir Run Run Shaw Hospital	Caabuqa Helicobacter Pylori	Febraayo 2016	Wajiga 4
NCT03465774	MD Anderson Cancer Center \| Machadka Qaranka ee Kansarka (NCI)	Dhiigbax Xun	Maarso 8, 2018	Wajiga hore 1