Canagliflozin

Sharax Gaaban:

Magaca API Tilmaam Faahfaahinta US DMF  EU DMF  CEP
Canagliflozin Nooca 2aad ee sonkorowga Guriga Gudihiisa    

Faahfaahinta alaabta

Calaamadaha alaabta

FAAHFAAHINTA SOO SAARKA

Gundhig

Canagliflozin waa sheeko cusub, awood leh, aadna loo xushay soodhiyam gulukooska co-transporter (SGLT) 2 inhibitor [1]. Waxaa la cadeeyay in Canagliflozin ay kordhin karto ka saarida gulukooska ee kaadi iyadoo la yareeyo xadka gulukooska kelyaha iyo iyadoo la yareeyo dib u nuugista gulukooska ee la sifeeyay [2].

Canagliflozin ayaa la muujiyey inuu xakameynayo qaadashada Na +-dhexdhexaad 14C-AMG ee CHO-hSGLT2, CHO-rat SGLT2 iyo CHO-mouse SGLT2 oo leh qiyamka IC50 ee 4.4, 3.7 iyo 2.0 nM, siday u kala horreeyaan [1].

Canagliflozin ayaa lagu soo warramey inay yareyneyso heerarka gulukoosta dhiigga (BG) qiyaasta ku tiirsan labada jiir db / db iyo Jiirka dufanka leh ee Zucker (ZDF). Intaa waxaa sii dheer, canagliflozin wuxuu cadeeyay inuu yareynayo saamiga sarifka neefsiga, iyo culeyska jirka ee jiirka DIO iyo jiirka ZDF [1].

Canagliflozin afka ayaa lagu qaadan karaa [1].

Tixraacyo:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Saamaynta canagliflozin ee marinka kelyaha loogu talagalay sonkorta, glycemia, iyo culeyska jirka ee moodooyinka xoolaha caadiga ah iyo kuwa macaanka leh. QAADO Hal. 2012; 7 (2): e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), oo ah Wakiilka Afka Novel ee Nooca-2 Sonkorowga. P T. 2013 Nofeembar; 38 (11): 656-66

Xigasho Badeecad

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, iyo al. "Farsamooyin kala duwan oo xallin loogu talagalay maareynta muraayadaha is-dulsaaran: Codsiga go'aaminta dawooyinka cusub ee isku-dhafan ee hypoglycemic ee isku-darka qiyaasta daawadooda." Spectrochimica Acta Qaybta A: Skoleetigga Molecular iyo Biomolecular Waxaa laga heli karaa khadka tooska ah 20 Juun 2018.

Qaab dhismeedka kiimikada

Canagliflozin

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

MAAMULKA TAYO

Quality management1

Soo jeedin 18 Mashaariicda Qiimaynta Joogtada Tayo ee la ansixiyay 4, iyo 6 mashaariicdii waa la ansixinayaa.

Quality management2

Nidaamka maaraynta tayada caalamiga ah ee horumarsan ayaa aasaas adag u dhigay iibka.

Quality management3

Kormeerka tayada ayaa maraya wareegga nolosha oo dhan ee badeecada si loo hubiyo tayada iyo saameynta daaweynta. 

Quality management4

Kooxda Xakamaynta Xirfadleyda waxay taageertaa baahiyaha tayada inta lagu jiro arjiga iyo diiwaangelinta.

MAAMULKA SOO-SAARKA

cpf5
cpf6

Khadka Ku Baakadeeya Dhalada Kuuriya Countec

cpf7
cpf8

Khadka Taakulaynta Caaga Tayada ee Taiwan CVC

cpf9
cpf10

Khadka Baakadaha ee Guddiga CAM ee Talyaaniga

cpf11

Mashiinka Isku-dhafka ah ee Jarmalka

cpf12

Japan Viswill Kiniin Baadhaha

cpf14-1

Qolka Xakamaynta DCS

WADAJIR

Iskaashiga caalamiga ah
International cooperation
Wadashaqeynta gudaha
Domestic cooperation

  • Hore:
  • Xiga:

  • Halkan ku qor fariintaada oo noo soo dir

    Qaybaha alaabta