Daclatasvir Dihydrochloride
Sharaxaada
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) waa awood afka ah oo firfircoon.borotiinka HCV NS5Aka hortag lehEC50inta u dhaxaysa 9-146 pM eenoocyo badan oo HCV replicon genotypes.Daclatasvir dihydrochloride sidoo kale waa aAnion organic gaadiidka polypeptide 1B (OATP1B)iyoOATP1B3ka hortag lehIC50s ee 1.5 µM iyo 3.27 µM, siday u kala horreeyaan.
IC50& Bartilmaameedka
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) iyo 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) iyo 3.27 µM (OATP1B3)[3]
In Vitro
Daclatasvir (BMS-790052) waxay muujisaa firfircoonida ka hortagga xoogga leh ee dhammaan noocyada genotypes ee la tijaabiyay, oo leh EC50qiyamka u dhexeeya 9 pM ilaa 146 pM.Daclatasvir waxay joojisaa HCV replicon genotype 1a, 1b, 2a, 3a, 4a and 5a with EC50qiimaha 50 pM, 9 pM, 71 pM, 146 pM, 12 pM iyo 33 pM, siday u kala horreeyaan.Daclatasvir waa horjooge awood leh oo ka mid ah JFH-1 genotype 2a fayraska faafa kaas oo ku soo noqnoqda dhaqanka unugyada (EC)50=28 pM)[1].Daclatasvir (BMS-790052) waxay si adag ugu xidhan tahay NS5A33-202 iyo NS5A26-202 oo wata Kds ee 8 nM iyo 210 nM, siday u kala horreeyaan[2].
Kaydinta
| Budada | -20°C | 3 sano |
| 4°C | 2 sano | |
| Ku milmay | -80°C | 6 bilood |
| -20°C | 1 bil |
Tijaabo Caafimaad
| Lambarka NCT | Kafiil | Xaalad | Taariikhda billowga | Marxaladda |
| NCT03369327 | Jaamacadda Tehran ee Sayniska Caafimaadka|Shirkadda Dawooyinka ee Rojan Pharma | Caabuqa Cagaarshowga C, Ka-jawaabista Daaweynta | Fayraska difaaca jirka | Janaayo 1, 2017 | Wajiga 3 |
| NCT03485846 | R-Pharm|Almedis | Cagaarshowga Chronic Genotype 1b | November 27, 2017 | Wajiga 2 |
| NCT01016912 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | December 2009 | Wajiga 2 |
| NCT01629732 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Maarso 2013 | Wajiga 2 |
| NCT01497834 | Bristol-Myers Squibb | Cagaarshow C | Janaayo 2012 | Wajiga 3 |
| NCT01973049 | Bristol-Myers Squibb | Cagaarshow C | December 2013 | Wajiga 3 |
| NCT00663208 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | May 2008 | Wajiga 2 |
| NCT02576314 | Xarunta Cilmi-baarista ee Aadanaha iyo Caafimaadka | Beijing 302 Hospital | Caabuqa Cagaarshowga C ee joogtada ah | May 2015 | Wajiga 3 |
| NCT02756936 | Xarunta Cilmi-baarista dhabta ah, Masar| Warshadaha Dawooyinka ee Zeta Pharma | Caafimaad qaba | Febraayo 2016 | Wajiga 1 |
| NCT02771405 | Hepatology Qaranka & Machadka Cilmi-baarista Daawada Kulaylaha|Jaamacadda Qaahira | Cagaarshowga C, Chronic|Kanarka Cagaarshowga | Maarso 2016 | Wajiga 3 |
| NCT03706898 | Viriom | HIV-1-infection|Hepatic Naafo | Oktoobar 1, 2018 | Wajiga 1 |
| NCT02319031 | Bristol-Myers Squibb | Cagaarshow C | Febraayo 2015 | Wajiga 3 |
| NCT02124044 | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Infekshinka (NIAID)|Bristol-Myers Squibb | HIV-HCV | Febraayo 2014 | Wajiga 2 |
| NCT02551861 | Bristol-Myers Squibb | Cagaarshow C | December 2015 | Wajiga 2 |
| NCT00859053 | Bristol-Myers Squibb | Cagaarshowga oo yaraada | Maarso 2009 | Wajiga 1 |
| NCT01257204 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | December 2010 | Wajiga 2 |
| NCT03063879 | Jaamacadda Tehran ee Sayniska Caafimaadka|Ahvaz Jundishapur Jaamacadda Sayniska Caafimaadka | Jaamacadda Shiraz ee Sayniska Caafimaadka | Jaamacadda Hamadan | Cagaarshowga C, Chronic|Renal Failure | Abriil 1, 2017 | Wajiga 4 |
| NCT01017575 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | December 2009 | Wajiga 2 |
| NCT02865369 | Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Cagaarshowga C ee joogtada ah | Sebtembar 2016 |
|
| NCT04070235 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Cagaarshowga C, Joogtada ah | Maarso 29, 2019 | Wajiga 2|Wejiga 3aad |
| NCT03487848 | Bristol-Myers Squibb | Cagaarshowga C|Cagaarshowga joogtada ah | May 18, 2018 | Wajiga 2 |
| NCT00904059 | Bristol-Myers Squibb | Cagaarshow C | May 2009 | Wajiga 1 |
| NCT02107365 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka ee Faransiiska - Hay'adda Qaranka ee Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS)|Bristol-Myers Squibb | Cagaarshowga C Virus Genotype 4 Caabuqa | November 2013 | Wajiga 2 |
| NCT02397395 | Janssen R&D Ireland | Impairment Kelyaha | May 2015 | Wajiga 2 |
| NCT03169348 | Jaamacadda Assiut | Cagaarshow C | November 1, 2017 | Ma khuseyso |
| NCT02323594 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | December 2014 | Wajiga 1 |
| NCT03537196 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka-Wakaaladda Qaranka Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS) | Cagaarshowga C| Isticmaalka Dawooyinka|Cagaarshowga C | November 13, 2018 | Wajiga 4 |
| NCT02103569 | Bristol-Myers Squibb | Cagaarshow C | Abriil 2014 | Wajiga 1 |
| NCT02772744 | Jaamacadda Zagazig|Jaamacadda Qaahira | Cagaarshow C | November 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Cagaarshow C | Janaayo 2013 | Wajiga 3 |
| NCT02496078 | Bristol-Myers Squibb | Cagaarshow C | Ogosto 2015 | Wajiga 3 |
| NCT01425970 | Bristol-Myers Squibb | Cagaarshow C | May 2012 | Wajiga 2 |
| NCT01471574 | Bristol-Myers Squibb | Cagaarshowga C, Genotype 1 | December 2011 | Wajiga 3 |
| NCT01573351 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | May 2012 | Wajiga 3 |
| NCT01938625 | Janssen R&D Ireland | Cagaarshowga C, Joogtada ah | December 12, 2013 | Wajiga 2 |
| NCT01492426 | Bristol-Myers Squibb | Cagaarshow C | Janaayo 2012 | Wajiga 3 |
| NCT03480932 | Dugsiga Johns Hopkins Bloomberg ee Caafimaadka Dadweynaha|Machadka Qaranka ee Xad-gudubka Daroogada (NIDA)|YR Gaitonde Xarunta Cilmi-baarista iyo Waxbarashada AIDS-ka | Cagaarshowga C, Joogtada ah | Febraayo 2, 2018 | Wajiga 2|Wejiga 3aad |
| NCT03163849 | Jaamacadda Assiut | Cagaarshowga joogtada ah c | Sebtember 1, 2019 | Wajiga 3 |
| NCT01581203 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | May 2012 | Wajiga 3 |
| NCT01492504 | Bristol-Myers Squibb | Cagaarshow C | February 7, 2012 |
|
| NCT03686722 | Mohamed Raslan|Jaamacada Ain Shams|Xarunta Cilmi Baadhista Daroogada, Qaahira, Masar | Sonkorowga Mellitus, Nooca 2|Cagaarshowga C|Isdhexgalka Daroogada | Sebtember 9, 2017 | Wajiga 1 |
| NCT02262728 | Janssen Cilmi-baarista & Horumarinta, LLC | Cagaarshowga C, Joogtada ah | Sebtembar 30, 2014 | Wajiga 2 |
| NCT02349048 | Janssen Cilmi-baarista & Horumarinta, LLC | Fayraska Cagaarshowga C | Janaayo 2015 | Wajiga 2 |
| NCT03882307 | Jaamacadda Assiut | Cagaarshowga C, Joogtada ah | May 2020 | Wajiga hore 1 |
| NCT02758509 | Parc de Salut Mar | Cagaarshowga C |Cirrhosis | Janaayo 1, 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Cagaarshow C | Maarso 2013 | Wajiga 2 |
| NCT03549832 | Jaamacadda Assiut | Jaamacadda Sohag | Jaamacadda South Valley | HCV Coinfection | Janaayo 1, 2018 | Ma khuseyso |
| NCT02161939 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah |
| |
| NCT01309932 | Bristol-Myers Squibb | Cagaarshow C | Maarso 2011 | Wajiga 2 |
| NCT01995266 | Bristol-Myers Squibb | Cagaarshow C | February 28, 2014 | Wajiga 3 |
| NCT02640157 | AbbVie | Cagaarshowga C ee raaga | Fayraska Cagaarshowga C | December 2015 | Wajiga 3 |
| NCT02032875 | Bristol-Myers Squibb | Cagaarshow C | Maarso 2014 | Wajiga 3 |
| NCT02624063 | Jaamacadda Federaalka ee São Paulo | Cagaarshowga C, Joogtada ah | December 2015 | Wajiga 4 |
| NCT00546715 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | November 2007 | Wajiga 1|Wejiga 2aad |
| NCT01718145 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | November 2012 | Wajiga 3 |
| NCT01616524 | Bristol-Myers Squibb | Cagaarshowga C (HCV) | Luulyo 2012 | Wajiga 3 |
| NCT02032901 | Bristol-Myers Squibb | Cagaarshow C | Janaayo 2014 | Wajiga 3 |
| NCT03540212 | Jaamacadda Ain Shams | Caabuqa HCV ee daba-dheeraaday | December 10, 2017 | Wajiga 2|Wejiga 3aad |
| NCT02097966 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah |
| |
| NCT02596880 | Jaamacadda Tehran ee culuumta caafimaadka | Cagaarshowga C|Cirrhosis | Sebtembar 2015 | Wajiga 3 |
| NCT04019717 | Hal qayb oo ka mid ah Atea Pharmaceuticals, Inc. | Cagaarshowga C|Cagaarshowga C, Cagaarshowga C, Chronic|Cagaarshowga C | Cagaarshowga C | Juun 20, 2019 | Wajiga 2 |
| NCT02992457 | Jaamacadda Tanta | Cagaarshow C | Janaayo 2015 | Wajiga 4 |
| NCT03547895 | Jaamacadda Zagazig | Cirrhosis-ka-baxa | Juun 1, 2015 | Ma khuseyso |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Chang Gung Memorial Hospital | National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan | Cagaarshow C | November 2016 | Wajiga 3 |
| NCT01051414 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Abriil 2010 | Wajiga 2 |
| NCT02309450 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka ee Faransiiska - Hay'adda Qaranka ee Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS)|Bristol-Myers Squibb | Cagaarshowga C Virus Genotype 4 Caabuqa | December 2014 | Wajiga 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Fayraska Cagaarshowga C | Luulyo 2012 | Wajiga 2 |
| NCT03186313 | Isbitaalka Beerka Masar|Cisbitaalka Waadi El Nil | Cagaarshow C | Sebtembar 2016 | Wajiga 3 |
| NCT03063723 | Isbitaalka Saddexaad ee Xiriirsan, Jaamacadda Sun Yat-Sen | Cagaarshowga C (Chronic Hepatitis) | Janaayo 1, 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | Oktoobar 2009 | Wajiga 1 |
| NCT01725542 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka ee Faransiiska - Hay'adda Qaranka ee Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS)|Bristol-Myers Squibb | Caabuqa HCV-HIV | December 2012 | Wajiga 2 |
| NCT02282709 | Aasaaska Cilmi-baarista Beerka | Cagaarshowga C ee joogtada ah | Febraayo 2014 | Wajiga 3 |
| NCT02032888 | Bristol-Myers Squibb | Cagaarshow C | Febraayo 2014 | Wajiga 3 |
| NCT03247296 | Jaamacadda MTI | Cagaarshow C | Febraayo 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Cagaarshow C | Sebtembar 2011 | Wajiga 3 |
| NCT02556086 | Bristol-Myers Squibb | Cagaarshow C | December 2015 | Wajiga 2 |
| NCT01741545 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Maarso 31, 2013 | Wajiga 3 |
| NCT01866930 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C ee joogtada ah | July 11, 2013 | Wajiga 3 |
| NCT02268864 | Janssen-Cilag International NV | Cagaarshowga C, Joogtada ah | Janaayo 2015 | Wajiga 2 |
| NCT01797848 | Bristol-Myers Squibb | Cagaarshow C | Juun 2014 | Wajiga 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Jaamacada Assiut | Cagaarshow C | Juun 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Cagaarshow C | Juun 2014 | Wajiga 1 |
| NCT01125189 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Luulyo 2010 | Wajiga 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Isdhexgalka daroogada | November 19, 2018 | Wajiga 1 |
| NCT01012895 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | December 2009 | Wajiga 2 |
| NCT02565888 | Jaamacadda Radboud | Cagaarshowga C|HIV | November 2015 | Wajiga 1 |
| NCT02555943 | Xarunta Cilmi-baarista ee Aadanaha iyo Caafimaadka | Isbitaalka Beijing 302 | Isbitaalka Nanfang ee Jaamacadda Caafimaadka Koonfurta | Caabuqa Cagaarshowga C ee daba-dheeraada | Febraayo 2015 | Wajiga 2|Wejiga 3aad |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Xarunta Cilmi-baarista ee Koonfurta California | Cagaarshowga C|Cirrhosis | Janaayo 2015 | Wajiga 4 |
| NCT02580474 | Myeong Jun Song | Bristol-Myers Squibb , Kuuriya|Cisbitaalka Severance|Isbitaal Guro University Korea|Eulji General Hospital|Jaamacada Katooliga ee Kuuriya | Cagaarshow C | Febraayo 2016 | Wajiga 4 |
| NCT02104843 | Bristol-Myers Squibb | Cagaarshow C | Abriil 2014 | Wajiga 1 |
| NCT01428063 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Sebtembar 2011 | Wajiga 2 |
| NCT02123654 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Abriil 2014 | Wajiga 3 |
| NCT02565862 | Jaamacadda Radboud | Cagaarshowga C|Sonkorowga Mellitus|Cabbiska Insulinta | Janaayo 2016 | Wajiga 1 |
| NCT04211844 | Jaamacadda Ain Shams | Cagaarshowga C ee joogtada ah | Oktoobar 1, 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Juun 2009 | Wajiga 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute ee Sayniska Caafimaadka | Kelyaha oo Fashilmay, Chronic|Hepatitis C | Maarso 15, 2019 | Wajiga 3 |
| NCT01448044 | Bristol-Myers Squibb | Cagaarshow C | December 2011 | Wajiga 3 |
| NCT01359644 | Bristol-Myers Squibb|Farmashiistaha | Cagaarshowga C ee joogtada ah | Juun 2011 | Wajiga 2 |
| NCT01842451 | Waa maxay faa'iidada saamileyda ah ee Vertex Pharmaceuticals Incorporated | Cagaarshowga Chronic C|CHC|HCV|Cagaarshowga C | Juun 2013 | Wajiga 2 |
| NCT02762448 | Isbitaalka degmada Tainan | Cagaarshow c | Luulyo 2016 |
|
| NCT02473211 | Xarunta Cilmi-baarista ee Aadanaha iyo Caafimaadka | Beijing 302 Hospital | Caabuqa Cagaarshowga C ee joogtada ah | Janaayo 2015 | Wajiga 2|Wejiga 3aad |
| NCT01455090 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | November 30, 2011 | Wajiga 2 |
| NCT03490097 | Jaamacadda Ain Shams | Cagaarshowga joogtada c|Metabolic Syndrome | December 1, 2017 | Wajiga 2|Wejiga 3aad |
| NCT01170962 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Ogosto 2010 | Wajiga 2 |
| NCT02333292 | Isbitaalka Jaamacadda Valme|Isbitaal del SAS de Jerez|Csbitaalka Guud Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real | Isbitaalka Universitario Virgen de la Universitario Isbitaalka Guud Universitario de Alicante|Hospital Universitario Araba|Isbitaal Royo Vilanova|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia de Cordoba|Csbitalka Universitario Virgen Macarena Navarra | Isbitaalka Clinico Universitario San Cecilio | Isbitaalka Universitario La Fe | Isbitaalka Guud Universitario de Valencia | Isbitaalka Universitario Infanta Leonor la Luz|Csbitaalka Guud Universitario de Castellón|Hospital Parc Taulí, Sabadell | Caabuqa Cagaarshowga C ee joogtada ah | December 2014 |
|
| NCT03200184 | Jaamacadda Tehran ee culuumta caafimaadka | Cagaarshow C | Sebtembar 1, 2016 | Wajiga 4 |
| NCT03188276 | Isbitaalka Saddexaad ee Xiriirsan, Jaamacadda Sun Yat-Sen | Cagaarshowga C ee joogtada ah | Febraayo 1, 2016 | Wajiga hore 1 |
| NCT01830205 | Bristol-Myers Squibb | Cagaarshow C | Sebtembar 2012 | Wajiga 1 |
Soo jeedin18Mashaariicda Qiimaynta Joogtada Tayada ee la ansixiyay4iyo6mashaariicda ayaa ku socda ansixinta.
Nidaamka maaraynta tayada sare ee caalamiga ah ayaa dhigay aasaas adag oo iib ah.
Kormeerka tayada wuxuu ku socdaa dhammaan wareegga nolosha ee alaabta si loo hubiyo tayada iyo saameynta daaweynta.
Kooxda Arrimaha Sharciyaynta Xirfadlayaasha waxay taageertaa shuruudaha tayada inta lagu jiro codsiga iyo diiwaangelinta.
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