Agomelatine

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Agomelatine Niyad jab Guriga Gudihiisa    

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Agomelatine waa agonist of melatonin receptors iyo antagonist of serotonin 5-HT2C reseptor oo leh qiyamka Ki ee 0.062nM iyo 0.268nM iyo qiimaha IC50 ee 0.27μM, siday u kala horreeyaan MT1, MT2 iyo 5-HT2C [1].

Agomelatine waa antidepressant gaar ah waxaana loogu talagalay daaweynta xanuunka weyn ee niyadjabka (MDD). Agomelatine wuxuu xushay 5-HT2C. Waxay muujineysaa xiriir hooseeya bini-aadamka 5-HT2A iyo 5-HT1A. Daawooyinka melatonin, agomelatine waxay muujineysaa isku xirnaansho la mid ah MT1 aadanaha iyo MT2 oo leh qiyamka Ki ee 0.09nM iyo 0.263nM, siday u kala horreeyaan. Daraasadaha ku jira vivo, agomelatine wuxuu keenaa kororka dopamine iyo heerarka noradrenaline iyadoo la adeegsanayo xannibaadda ka-hortagga 5-HT2C. Intaa waxaa sii dheer, maamulka agomelatine wuxuu ka hortagayaa hoos u dhaca walaaca ee ku yimid isticmaalka sukrose ee qaabka jiirka ee niyadjabka. Taas ka sokow, agomelatine wuxuu sameeyaa yareynta waxtarka walaaca ee qaabka jiirka ee walwalka [1].

Tixraacyo:
[1] Zupancic M, Guilleminault C. Agomelatine. Dawooyinka CNS, 2006, 20 (12): 981-992.

Qaab dhismeedka kiimikada

Agomelatine

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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