Agomelatine
Asalkii hore
Agomelatine waa agonist of melatonin reseptors iyo antagonist ee serotonin 5-HT2C reseptor leh Ki qiyamka 0.062nM iyo 0.268nM iyo IC50 qiimaha 0.27μM, siday u kala horreeyaan MT1, MT2 iyo 5-HT2C [1].
Agomelatine waa daawada niyad-jabka ee gaarka ah waxaana loo sameeyay daawaynta xanuunka weyn ee niyad-jabka (MDD).Agomelatine wuxuu ka door bidaa 5-HT2C.Waxay muujinaysaa xidhiidh hoose oo ay la leedahay bini'aadamka 5-HT2A iyo 5-HT1A.Soo-dhoweeyayaasha melatonin, agomelatine waxay tusinaysaa xidhiidh la mid ah bini'aadamka MT1 iyo MT2 oo leh qiyamka Ki ee 0.09nM iyo 0.263nM, siday u kala horreeyaan.Daraasadaha in vivo, agomelatine waxay sababtaa kororka dopamine iyo heerarka noradrenaline iyadoo la xakameynayo soo-gelinta xannibaadda ee 5-HT2C.Intaa waxaa dheer, maamulka agomelatine wuxuu ka hortagayaa hoos u dhaca kadeedka ay keentay isticmaalka sukrose ee qaabka jiirka ee niyad-jabka.Taas ka sokow, agomelatine waxay yareysaa waxtarka welwelka ee qaabka walaaca ee jiirka [1].
Tixraacyo:
[1] Zupancic M, Guilleminault C. Agomelatine.Daawooyinka CNS, 2006, 20 (12): 981-992.
Qaab dhismeedka kiimikada
Soo jeedin18Mashaariicda Qiimaynta Joogtada Tayada ee la ansixiyay4iyo6mashaariicda ayaa ku socda ansixinta.
Nidaamka maaraynta tayada sare ee caalamiga ah ayaa dhigay aasaas adag oo iib ah.
Kormeerka tayada wuxuu ku socdaa dhammaan wareegga nolosha ee alaabta si loo hubiyo tayada iyo saameynta daaweynta.
Kooxda Arrimaha Sharciyaynta Xirfadlayaasha waxay taageertaa shuruudaha tayada inta lagu jiro codsiga iyo diiwaangelinta.
Khadka Baakadaha ee Countec ee Kuuriya
Khadka baakadaha dhalada ee Taiwan CVC
Taliyaaniga CAM Khadka Baakadaha
Jarmal Fette Machine Compacting
Japan Viswill Tablet Detector
Qolka Xakamaynta DCS
