Pomalidomide, oo hore loogu yiqiin CC-4047 ama actimid, waa unug awood leh oo immunomodulatory ah oo muujiya waxqabadka antineoplastic ee daaweynta malignancies hematological, gaar ahaan soo noqoshada iyo dib u soo noqoshada myeloma Multiple (MM). Sida derivative of thalidomide, pomalidomide waxay leedahay qaab-dhismeedka kiimikaad la mid ah sida thalidomide marka laga reebo isku darka laba kooxood oo oxo ah ee giraanta phthaloyl iyo kooxda amino ee booska afraad. Guud ahaan, sida molecule immunomodulatory ah, pomalidomide wuxuu muujiyaa waxqabadka antitumor iyada oo loo marayo hab lagu xakameynayo microenvironment burada iyadoo la beddelayo cytokines taageera burada (TNF-α, IL-6, IL-8 iyo VEGF), si toos ah hoos u habeynta hawlaha muhiimka ah ee burada unugyo, iyo ka qayb qaadashada taageerada unugyada aan difaaca lahayn ee martida loo yahay.

Pomalidomide waxa loo isticmaalaa in lagu daweeyo dhowr myeloma (kansar ka dhashay cudur dhiig oo sii socda). Pomalidomide waxaa badanaa la bixiyaa ka dib markii ugu yaraan laba daawo oo kale la isku dayay guul la'aan.

Pomalidomide waxa kale oo loo isticmaalaa in lagu daweeyo AIDS-ka la xidhiidha Kaposi sarcoma marka daawooyinka kale aanay shaqayn ama ay joojiyaan shaqada. pomalimide sidoo kale waxaa loo isticmaali karaa in lagu daaweeyo Kaposi Sarcoma ee dadka qaangaarka ahHIV-negative.

Pomalidomide waxa laga heli karaa farmashiye shahaado haysta oo hoos yimaada barnaamij gaar ah. Waa in aad ka diiwaan gashan tahay barnaamijka oo aad ogolaato in aad isticmaashoxakameynta dhalmadatallaabooyinka loo baahan yahay.

Pomalidomide waxa kale oo loo isticmaali karaa ujeedooyin aan ku xusnayn hagaha daawaynta.

Pomalidomide waxay sababi kartaa cillado dhalmo oo daran, oo nafta halis gelisa ama dhimashada ilmaha haddii hooyada ama aabaha ay qaadanayaan pomalidomide wakhtiga uurka ama xilliga uurka. Xitaa hal dose oo ah pomalidomide wuxuu sababi karaa cilladaha waaweyn ee gacmaha iyo lugaha ilmaha, lafaha, dhegaha, indhaha, wejiga, iyo wadnaha. Weligaa ha isticmaalin pomalidomide haddii aad uur leedahay. Isla markiiba u sheeg dhakhtarkaaga haddii caadadaadu soo daahday markaad qaadanayso pomalidomide.