Kalsiyamta loo yaqaan Pitavastatin

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Kalsiyamta loo yaqaan Pitavastatin Hypercholesterolemia Guriga Gudihiisa      

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伐 他 汀 钙 Pitavastatin 147526-32-7 Guriga Gudihiisa
    PI-5 3800-06-4 Guriga Gudihiisa
    PI-6 145516-11-4 Guriga Gudihiisa
    PI-7 121660-11-5 Guriga Gudihiisa

 

Sharaxaad

Kalsiyamta loo yaqaan 'Pitavastatin Calcium' (NK-104 hemicalcium) waa xoog hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Kalsiyamta loo yaqaan 'Pitavastatin Calcium' (NK-104 hemicalcium) waxay joojisaa isku-darka kolestaroolka laga helo acetic acid oo leh IC50 oo ah 5.8 nM unugyada HepG2. Kalsiyam-ka loo yaqaan 'Pitavastatin Calcium' waa wax-ku-ool ah hepatocyte lipoprotein-cholesterol (LDL-C) soo-saare soo-qaadaha. Waxqabadka ka hortagga kansarka.

 

Gundhig

Kalsiyamta loo yaqaan 'Pitavastatin Calcium' waa horjoogsade ka-hortagga enzyme-ka HMGCR (HMG-CoA reductase) natiijooyinka hoos u dhigista isku-darka kolestaroolka LDL. Daraasado kale ayaa muujinaya in pitavastatin uu xakamayn karo wax soo saarka oksijiinta ee unugyada endothelial iyadoo la joojinayo NADPH oxidase. Intaa waxaa sii dheer, pitavastatin wuxuu yareynayaa muujinta eNOS mRNA iyadoo la kordhinayo jawaab celinta ku tiirsanaanta MAYA ee ay kiciso acetylcholine iyo kalsiyum ionophore, A23187. Intaa waxaa sii dheer, pitavastatin wuxuu xakameynayaa hagaajinta kor u qaadista marinnada kalsiyum-ku-shaqeysiga ah iyadoo hoos loo dhigayo heerarka kolestaroolka ee unugyada.

 

Kaydinta

4°C, ka ilaali iftiinka

* Kala-baxa: -80°C, 6 bilood; -20°C, 1 bil (ka ilaali iftiinka)

 

Qaab dhismeedka kiimikada

Pitavastatin Calcium

Xogta Biyolojiga ee la Xiriira

Pitavastatin Calcium2

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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