Sharaxaada

Calcium Pitavastatin (NK-104 hemicalcium) waa hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor oo awood leh. Calcium Pitavastatin (NK-104 hemicalcium) waxay joojisaa isku-dhafka kolestaroolka acetic acid oo leh IC50 ee 5.8 nM ee unugyada HepG2. Calcium-ka Pitavastatin waa beeryaro wax-ku-ool ah oo wax-ku-ool ah-cufnaanta-hooseeya ee lipoprotein-cholesterol (LDL-C). Dhaqdhaqaaqa ka hortagga kansarka.

Asalkii hore

Calcium Pitavastatin waa horjooge tartan u ah enzyme HMGCR (HMG-CoA reductase) waxay keenaysaa hoos u dhigista kolestaroolka LDL. Daraasado kale ayaa muujinaya in pitavastatin ay xakamayn karto wax soo saarka oksijiinta ee unugyada endothelial iyadoo la joojinayo NADPH oxidase. Intaa waxaa dheer, pitavastatin waxay yaraynaysaa muujinta eNOS mRNA iyada oo kordhinaysa jawaabta NO ku tiirsanaanta ee ay kicisay acetylcholine iyo calcium ionophore, A23187. Intaa waxaa dheer, pitavastatin waxay xakameysaa hagaajinta hab-dhaqanka kanaalka potassium-ka-shaqeeya ee kalsiyumka iyadoo hoos u dhigaysa heerarka kolestaroolka ee unugyada.

Kaydinta

4°C, ka ilaali iftiinka

*Ku jirta dareere: -80°C, 6 bilood; -20°C, 1 bil (ka ilaali iftiinka)

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