Aashitada Asiidh

Sharax Gaaban:

Magaca API Tilmaam Faahfaahinta US DMF  EU DMF  CEP
Aashitada Asiidh Billaary cholangitis Guriga Gudihiisa      

Faahfaahinta alaabta

Calaamadaha alaabta

FAAHFAAHINTA SOO SAARKA

Sharaxaad

Obeticholic acid (INT-747) waa awood, xulasho iyo hadal firfircoon FXR agonist leh EC50 ee 99 nM. Obeticholic acid waxay leedahay daawada xasaasiyadeed iyo anti-bararka. Aashitada aaladda loo yaqaan 'Obeticholic acid' sidoo kale waxay dhalisaa autophagy [1] [2] [3].

 

Gundhig

Acid Obeticholic Acid (6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747) waa karti iyo xulasho agonist ah FXR oo leh qiimaha EC50 ee 99 nM [1].

Daawada 'farnesoid X receptor' (FXR) waa aaladda loo yaqaan 'nuclear bile acid receptor' oo ku lug leh bile acid homeostasis, beerka fibrosis, cagaarshow iyo xiidmaha oo barara iyo cudurrada wadnaha iyo xididdada [2].

Obeticholic Acid waa xoog leh oo xulasho FXR agonist leh waxqabadka xinjirowga lidka ku ah [1]. Obeticholic Acid waa nooc ka mid ah unugyada bile acid-ka loo yaqaan 'semisynthetic bile acid' iyo xoog Fandhaal FXR. Jiirarka loo yaqaan 'estrogen-induced cholestasis', 6-ECDCA ayaa laga ilaaliyaa cholestasis oo ay keento 17α-ethynylestradiol (E217α) [2]. Moodooyinka jiirka ee cirrhotic portal (PHT), INT-747 (30 mg / kg) waxay dib u hawlgelisay wadada calaamadaha hoose ee FXR iyo hoos u dhigista cadaadiska marinka iyadoo hoos loo dhigayo wadarta caabbinta xididdada dhiigga (IHVR) iyada oo aan hoos loo dhigin nidaamka hoos u dhaca. Saameyntani waxay la xiriirtay waxqabad eNOS oo kordhay [3]. Moodhka 'Dahl rat' ee dhiig karka xasaasiga ah ee cusbada iyo insulin-caabbinta (IR), cuntada cusbada badan (HS) waxay si weyn u kordhisay cadaadiska dhiigga ee nidaamka iyo muujinta unugyada hoos u dhaca ee DDAH INT-747 waxay xoojisay xasaasiyadda insulin-ta waxayna joojisay hoos u dhaca muujinta DDAH [4].

Tixraacyo:
[1]. Pellicciari R, Fiorucci S, Camaioni E, iyo al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), awood badan oo xulasho FXR agonist ah oo lagu siiyay waxqabadyo lidka ku ah. J Med Chem, 2002, 45 (17): 3569-3572.
[2] Fiorucci S, Clerici C, Antonelli E, iyo al. Saamaynta ka hortagga ee 6-ethyl chenodeoxycholic acid, a lignes farnesoid X, oo ku jirta estrogen-ku-kicinta cholestasis. J Pharmacol Exp Ther, 2005, 313 (2): 604-612.
[3]. Verbeke L, Farre R, Trebicka J, et al. Obeticholic acid, oo ah agonist soo-qaadaha farnesoid X, wuxuu hagaajiyaa dhiig-karka marinka laba wadiiqo oo kala duwan oo ku jira jiirka cirrhotic. Cagaarshowga, 2014, 59 (6): 2286-2298.
[4]. Ghebremariam YT, Yamada K, Lee JC, et al. FXR agonist INT-747 wuxuu hagaajiyaa muujinta DDAH wuxuuna xoojiyaa xasaasiyadda insulin ee jiirka Dahl ee cusbada sare leh. QAADO Mid, 2013, 8 (4): e60653.

Xigasho Badeecad

  • 1. Selina Costa. "Astaamaynta Noigga Ligand ee Farnesoid X Receptor iyadoo la adeegsanayo Transgenic Zebrafish." Jaamacadda Toronto. Jun-2018.
  • 2. Kent, Rebecca. "Saamaynta Fenofibrate ee CYP2D6 iyo Xeerka ANG1 iyo RNASE4 ee FXR Agonist Obeticholic Acid." indigo.uic.edu.2017.

 

Kaydinta

Budada

-20 ° C

3 sano
 

4 ° C

2 sano
Kala dareeraha

-80 ° C

6 bilood
 

-20 ° C

1 bil

Qaab dhismeedka kiimikada

Obeticholic Acid

Xogta Biyolojiga ee la Xiriira

Obeticholic Acid2

Xogta Biyolojiga ee la Xiriira

Obeticholic Acid3

SHAHAADO

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

MAAMULKA TAYO

Quality management1

Soo jeedin 18 Mashaariicda Qiimaynta Joogtada Tayo ee la ansixiyay 4, iyo 6 mashaariicdii waa la ansixinayaa.

Quality management2

Nidaamka maaraynta tayada caalamiga ah ee horumarsan ayaa aasaas adag u dhigay iibka.

Quality management3

Kormeerka tayada ayaa maraya wareegga nolosha oo dhan ee badeecada si loo hubiyo tayada iyo saameynta daaweynta. 

Quality management4

Kooxda Xakamaynta Xirfadleyda waxay taageertaa baahiyaha tayada inta lagu jiro arjiga iyo diiwaangelinta.

MAAMULKA SOO-SAARKA

cpf5
cpf6

Khadka Ku Baakadeeya Dhalada Kuuriya Countec

cpf7
cpf8

Khadka Taakulaynta Caaga Tayada ee Taiwan CVC

cpf9
cpf10

Khadka Baakadaha ee Guddiga CAM ee Talyaaniga

cpf11

Mashiinka Isku-dhafka ah ee Jarmalka

cpf12

Japan Viswill Kiniin Baadhaha

cpf14-1

Qolka Xakamaynta DCS

WADAJIR

Iskaashiga caalamiga ah
International cooperation
Wadashaqeynta gudaha
Domestic cooperation

  • Hore:
  • Xiga:

  • Halkan ku qor fariintaada oo noo soo dir

    Qaybaha alaabta