Daclatasvir Dihydrochloride
Sharaxaada
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) waa awood afka ah oo firfircoon.borotiinka HCV NS5Aka hortag lehEC50inta u dhaxaysa 9-146 pM eenoocyo badan oo HCV replicon genotypes. Daclatasvir dihydrochloride sidoo kale waa aAnion organic gaadiidka polypeptide 1B (OATP1B)iyoOATP1B3ka hortag lehIC50s ee 1.5 µM iyo 3.27 µM, siday u kala horreeyaan.
IC50& Bartilmaameedka
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) iyo 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) iyo 3.27 µM (OATP1B3)[3]
In Vitro
Daclatasvir (BMS-790052) waxay muujisaa firfircoonida ka hortagga xoogga leh ee ku wajahan dhammaan noocyada genotype ee la tijaabiyay, oo leh EC50qiyamka u dhexeeya 9 pM ilaa 146 pM. Daclatasvir waxay joojisaa HCV replicon genotype 1a, 1b, 2a, 3a, 4a and 5a with EC50qiimaha 50 pM, 9 pM, 71 pM, 146 pM, 12 pM iyo 33 pM, siday u kala horreeyaan. Daclatasvir waa horjooge awood leh oo ah JFH-1 genotype 2a fayraska faafa kaas oo ku soo noqnoqda dhaqanka unugyada (EC)50=28 pM)[1]. Daclatasvir (BMS-790052) waxay si adag ugu xidhan tahay NS5A33-202 iyo NS5A26-202 oo wata Kds ee 8 nM iyo 210 nM, siday u kala horreeyaan[2].
Kaydinta
| Budada | -20°C | 3 sano |
| 4°C | 2 sano | |
| Ku milmay | -80°C | 6 bilood |
| -20°C | 1 bil |
Tijaabo Caafimaad
| Lambarka NCT | Kafiil | Xaalad | Taariikhda Bilawga | Marxaladda |
| NCT03369327 | Jaamacadda Tehran ee Sayniska Caafimaadka|Shirkadda Dawooyinka ee Rojan Pharma | Caabuqa Cagaarshowga C, Ka-jawaabista Daaweynta | Fayraska difaaca jirka | Janaayo 1, 2017 | Wajiga 3 |
| NCT03485846 | R-Pharm|Almedis | Cagaarshowga Chronic Genotype 1b | November 27, 2017 | Wajiga 2 |
| NCT01016912 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | December 2009 | Wajiga 2 |
| NCT01629732 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Maarso 2013 | Wajiga 2 |
| NCT01497834 | Bristol-Myers Squibb | Cagaarshowga C | Janaayo 2012 | Wajiga 3 |
| NCT01973049 | Bristol-Myers Squibb | Cagaarshowga C | December 2013 | Wajiga 3 |
| NCT00663208 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | May 2008 | Wajiga 2 |
| NCT02576314 | Xarunta Cilmi-baarista ee Aadanaha iyo Caafimaadka | Beijing 302 Hospital | Caabuqa Cagaarshowga C ee joogtada ah | May 2015 | Wajiga 3 |
| NCT02756936 | Xarunta Cilmi-baarista dhabta ah, Masar| Warshadaha Dawooyinka ee Zeta Pharma | Caafimaad qaba | Febraayo 2016 | Wajiga 1 |
| NCT02771405 | Hepatology Qaranka & Machadka Cilmi-baarista Daawada Kulaylaha|Jaamacadda Qaahira | Cagaarshowga C, Chronic|Kanarka Cagaarshowga | Maarso 2016 | Wajiga 3 |
| NCT03706898 | Viriom | HIV-1-infection|Hepatic Naafo | Oktoobar 1, 2018 | Wajiga 1 |
| NCT02319031 | Bristol-Myers Squibb | Cagaarshowga C | Febraayo 2015 | Wajiga 3 |
| NCT02124044 | Machadka Qaranka ee Xasaasiyadda iyo Cudurada Infekshinka (NIAID)|Bristol-Myers Squibb | HIV-HCV | Febraayo 2014 | Wajiga 2 |
| NCT02551861 | Bristol-Myers Squibb | Cagaarshowga C | December 2015 | Wajiga 2 |
| NCT00859053 | Bristol-Myers Squibb | Cagaarshowga oo yaraada | Maarso 2009 | Wajiga 1 |
| NCT01257204 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | December 2010 | Wajiga 2 |
| NCT03063879 | Jaamacadda Tehran ee Sayniska Caafimaadka|Ahvaz Jundishapur Jaamacadda Sayniska Caafimaadka | Jaamacadda Shiraz ee Sayniska Caafimaadka | Jaamacadda Hamadan | Cagaarshowga C, Chronic|Renal Failure | Abriil 1, 2017 | Wajiga 4 |
| NCT01017575 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | December 2009 | Wajiga 2 |
| NCT02865369 | Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Cagaarshowga C ee joogtada ah | Sebtembar 2016 |
|
| NCT04070235 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Cagaarshow C, dabadheeraad ah | Maarso 29, 2019 | Wajiga 2|Wejiga 3aad |
| NCT03487848 | Bristol-Myers Squibb | Cagaarshowga C|Cagaarshowga joogtada ah | May 18, 2018 | Wajiga 2 |
| NCT00904059 | Bristol-Myers Squibb | Cagaarshowga C | May 2009 | Wajiga 1 |
| NCT02107365 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka ee Faransiiska - Hay'adda Qaranka ee Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS)|Bristol-Myers Squibb | Cagaarshowga C Virus Genotype 4 Caabuqa | November 2013 | Wajiga 2 |
| NCT02397395 | Janssen R&D Ireland | Impairment Kelyaha | May 2015 | Wajiga 2 |
| NCT03169348 | Jaamacadda Assiut | Cagaarshowga C | November 1, 2017 | Aan lagu dabaqi karin |
| NCT02323594 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | December 2014 | Wajiga 1 |
| NCT03537196 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka-Wakaaladda Qaranka Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS) | Cagaarshowga C| Isticmaalka Dawooyinka|Cagaarshowga C | November 13, 2018 | Wajiga 4 |
| NCT02103569 | Bristol-Myers Squibb | Cagaarshowga C | Abriil 2014 | Wajiga 1 |
| NCT02772744 | Jaamacadda Zagazig|Jaamacadda Qaahira | Cagaarshowga C | November 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Cagaarshowga C | Janaayo 2013 | Wajiga 3 |
| NCT02496078 | Bristol-Myers Squibb | Cagaarshowga C | Ogosto 2015 | Wajiga 3 |
| NCT01425970 | Bristol-Myers Squibb | Cagaarshowga C | May 2012 | Wajiga 2 |
| NCT01471574 | Bristol-Myers Squibb | Cagaarshowga C, Genotype 1 | December 2011 | Wajiga 3 |
| NCT01573351 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | May 2012 | Wajiga 3 |
| NCT01938625 | Janssen R&D Ireland | Cagaarshow C, dabadheeraad ah | December 12, 2013 | Wajiga 2 |
| NCT01492426 | Bristol-Myers Squibb | Cagaarshowga C | Janaayo 2012 | Wajiga 3 |
| NCT03480932 | Dugsiga Johns Hopkins Bloomberg ee Caafimaadka Dadweynaha|Machadka Qaranka ee Xad-gudubka Daroogada (NIDA)|YR Gaitonde Xarunta Cilmi-baarista iyo Waxbarashada AIDS-ka | Cagaarshow C, dabadheeraad ah | Febraayo 2, 2018 | Wajiga 2|Wejiga 3aad |
| NCT03163849 | Jaamacadda Assiut | Cagaarshowga joogtada ah c | Sebtember 1, 2019 | Wajiga 3 |
| NCT01581203 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | May 2012 | Wajiga 3 |
| NCT01492504 | Bristol-Myers Squibb | Cagaarshowga C | February 7, 2012 |
|
| NCT03686722 | Mohamed Raslan|Jaamacada Ain Shams|Xarunta Cilmi Baadhista Daroogada ee Qaahira, Masar | Sonkorowga Mellitus, Nooca 2|Cagaarshowga C|Isdhexgalka Daroogada | Sebtember 9, 2017 | Wajiga 1 |
| NCT02262728 | Janssen Research & Horumarinta, LLC | Cagaarshow C, dabadheeraad ah | Sebtembar 30, 2014 | Wajiga 2 |
| NCT02349048 | Janssen Research & Horumarinta, LLC | Fayraska Cagaarshowga C | Janaayo 2015 | Wajiga 2 |
| NCT03882307 | Jaamacadda Assiut | Cagaarshow C, dabadheeraad ah | May 2020 | Wajiga hore 1 |
| NCT02758509 | Parc de Salut Mar | Cagaarshowga C |Cirrhosis | Janaayo 1, 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Cagaarshowga C | Maarso 2013 | Wajiga 2 |
| NCT03549832 | Jaamacadda Assiut | Jaamacadda Sohag | Jaamacadda South Valley | HCV Coinfection | Janaayo 1, 2018 | Aan lagu dabaqi karin |
| NCT02161939 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah |
| |
| NCT01309932 | Bristol-Myers Squibb | Cagaarshowga C | Maarso 2011 | Wajiga 2 |
| NCT01995266 | Bristol-Myers Squibb | Cagaarshowga C | February 28, 2014 | Wajiga 3 |
| NCT02640157 | AbbVie | Cagaarshowga C ee raaga | Fayraska Cagaarshowga C | December 2015 | Wajiga 3 |
| NCT02032875 | Bristol-Myers Squibb | Cagaarshowga C | Maarso 2014 | Wajiga 3 |
| NCT02624063 | Jaamacadda Federaalka ee Sao Paulo | Cagaarshow C, dabadheeraad ah | December 2015 | Wajiga 4 |
| NCT00546715 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | November 2007 | Wajiga 1|Wejiga 2aad |
| NCT01718145 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | November 2012 | Wajiga 3 |
| NCT01616524 | Bristol-Myers Squibb | Fayraska Cagaarshowga C (HCV) | Luulyo 2012 | Wajiga 3 |
| NCT02032901 | Bristol-Myers Squibb | Cagaarshowga C | Janaayo 2014 | Wajiga 3 |
| NCT03540212 | Jaamacadda Ain Shams | Caabuqa HCV ee daba-dheeraaday | December 10, 2017 | Wajiga 2|Wejiga 3aad |
| NCT02097966 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah |
| |
| NCT02596880 | Jaamacadda Tehran ee culuumta caafimaadka | Cagaarshowga C|Cirrhosis | Sebtembar 2015 | Wajiga 3 |
| NCT04019717 | Hal qayb oo ka mid ah Atea Pharmaceuticals, Inc. | Cagaarshowga C|Cagaarshowga C, Cagaarshowga C, Chronic|Cagaarshowga C | Cagaarshowga C | Juun 20, 2019 | Wajiga 2 |
| NCT02992457 | Jaamacadda Tanta | Cagaarshowga C | Janaayo 2015 | Wajiga 4 |
| NCT03547895 | Jaamacadda Zagazig | Cirrhosis-ka-baxa | Juun 1, 2015 | Aan lagu dabaqi karin |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Chang Gung Memorial Hospital | National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan | Cagaarshowga C | November 2016 | Wajiga 3 |
| NCT01051414 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Abriil 2010 | Wajiga 2 |
| NCT02309450 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka ee Faransiiska - Hay'adda Qaranka ee Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS)|Bristol-Myers Squibb | Cagaarshowga C Virus Genotype 4 Caabuqa | December 2014 | Wajiga 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Fayraska Cagaarshowga C | Luulyo 2012 | Wajiga 2 |
| NCT03186313 | Isbitaalka Beerka Masar|Cisbitaalka Waadi El Nil | Cagaarshowga C | Sebtembar 2016 | Wajiga 3 |
| NCT03063723 | Isbitaalka Saddexaad ee Xiriirsan, Jaamacadda Sun Yat-Sen | Cagaarshowga C (Chronic Hepatitis) | Janaayo 1, 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | Oktoobar 2009 | Wajiga 1 |
| NCT01725542 | Machadka Qaranka ee Caafimaadka iyo Cilmi-baarista Caafimaadka ee Faransiiska - Hay'adda Qaranka ee Faransiiska ee Cilmi-baarista AIDS-ka iyo Cagaarshowga Fayraska (Inserm-ANRS)|Bristol-Myers Squibb | Caabuqa HCV-HIV | December 2012 | Wajiga 2 |
| NCT02282709 | Aasaaska Cilmi-baarista Beerka | Cagaarshowga C ee joogtada ah | Febraayo 2014 | Wajiga 3 |
| NCT02032888 | Bristol-Myers Squibb | Cagaarshowga C | Febraayo 2014 | Wajiga 3 |
| NCT03247296 | Jaamacadda MTI | Cagaarshowga C | Febraayo 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Cagaarshowga C | Sebtembar 2011 | Wajiga 3 |
| NCT02556086 | Bristol-Myers Squibb | Cagaarshowga C | December 2015 | Wajiga 2 |
| NCT01741545 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Maarso 31, 2013 | Wajiga 3 |
| NCT01866930 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C ee joogtada ah | July 11, 2013 | Wajiga 3 |
| NCT02268864 | Janssen-Cilag International NV | Cagaarshow C, dabadheeraad ah | Janaayo 2015 | Wajiga 2 |
| NCT01797848 | Bristol-Myers Squibb | Cagaarshowga C | Juun 2014 | Wajiga 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Jaamacada Assiut | Cagaarshowga C | Juun 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Cagaarshowga C | Juun 2014 | Wajiga 1 |
| NCT01125189 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Luulyo 2010 | Wajiga 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Isdhexgalka daroogada | November 19, 2018 | Wajiga 1 |
| NCT01012895 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | December 2009 | Wajiga 2 |
| NCT02565888 | Jaamacadda Radboud | Cagaarshowga C|HIV | November 2015 | Wajiga 1 |
| NCT02555943 | Xarunta Cilmi-baarista ee Aadanaha iyo Caafimaadka | Isbitaalka Beijing 302 | Isbitaalka Nanfang ee Jaamacadda Caafimaadka Koonfurta | Caabuqa Cagaarshowga C ee daba-dheeraada | Febraayo 2015 | Wajiga 2|Wejiga 3aad |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Xarunta Cilmi-baarista ee Koonfurta California | Cagaarshowga C|Cirrhosis | Janaayo 2015 | Wajiga 4 |
| NCT02580474 | Myeong Jun Song | Bristol-Myers Squibb , Kuuriya|Cisbitaalka Severance|Isbitaal Guro University Korea|Eulji General Hospital|Jaamacada Katooliga ee Kuuriya | Cagaarshowga C | Febraayo 2016 | Wajiga 4 |
| NCT02104843 | Bristol-Myers Squibb | Cagaarshowga C | Abriil 2014 | Wajiga 1 |
| NCT01428063 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Sebtembar 2011 | Wajiga 2 |
| NCT02123654 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Abriil 2014 | Wajiga 3 |
| NCT02565862 | Jaamacadda Radboud | Cagaarshowga C|Sonkorowga Mellitus|Cabbiska Insulinta | Janaayo 2016 | Wajiga 1 |
| NCT04211844 | Jaamacadda Ain Shams | Cagaarshowga C ee joogtada ah | Oktoobar 1, 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Caabuqa Cagaarshowga C | Juun 2009 | Wajiga 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute ee Sayniska Caafimaadka | Kelyaha oo Fashilmay, Chronic|Hepatitis C | Maarso 15, 2019 | Wajiga 3 |
| NCT01448044 | Bristol-Myers Squibb | Cagaarshowga C | December 2011 | Wajiga 3 |
| NCT01359644 | Bristol-Myers Squibb|Farmashiistaha | Cagaarshowga C ee joogtada ah | Juun 2011 | Wajiga 2 |
| NCT01842451 | Waa maxay faa'iidada saamileyda ah ee Vertex Pharmaceuticals Incorporated | Cagaarshowga Chronic C|CHC|HCV|Cagaarshowga C | Juun 2013 | Wajiga 2 |
| NCT02762448 | Isbitaalka degmada Tainan | Cagaarshow c | Luulyo 2016 |
|
| NCT02473211 | Xarunta Cilmi-baarista ee Aadanaha iyo Caafimaadka | Beijing 302 Hospital | Caabuqa Cagaarshowga C ee joogtada ah | Janaayo 2015 | Wajiga 2|Wejiga 3aad |
| NCT01455090 | Bristol-Myers Squibb | Cagaarshowga C ee joogtada ah | November 30, 2011 | Wajiga 2 |
| NCT03490097 | Jaamacadda Ain Shams | Cagaarshowga joogtada c|Metabolic Syndrome | December 1, 2017 | Wajiga 2|Wejiga 3aad |
| NCT01170962 | Bristol-Myers Squibb | Fayraska Cagaarshowga C | Ogosto 2010 | Wajiga 2 |
| NCT02333292 | Isbitaalka Jaamacadda Valme | Isbitaalka del SAS de Jerez Isbitaalka Guud Jaamacadda Universitario de Alicante Universidad de Navarra | Isbitaalka Clinico Universitario San Cecilio | Isbitaalka Universitario La Fe | Isbitaalka Guud Universitario de Valencia Haya|Isbitaal Virgen de la Luz|Csbitaalka Guud Universitario de Castellón|Hospital Parc Taulí, Sabadell | Caabuqa Cagaarshowga C ee joogtada ah | December 2014 |
|
| NCT03200184 | Jaamacadda Tehran ee culuumta caafimaadka | Cagaarshowga C | Sebtembar 1, 2016 | Wajiga 4 |
| NCT03188276 | Isbitaalka Saddexaad ee Xiriirsan, Jaamacadda Sun Yat-Sen | Cagaarshowga C ee joogtada ah | Febraayo 1, 2016 | Wajiga hore 1 |
| NCT01830205 | Bristol-Myers Squibb | Cagaarshowga C | Sebtembar 2012 | Wajiga 1 |
Soo jeedin18Mashaariicda Qiimaynta Joogtada Tayada ee la ansixiyay4iyo6mashaariicda ayaa ku socda ansixinta.
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