Dabigatran Etexilate Mesylate
Sharaxaada
Dabigatran etexilate mesylate (BIBR 1048MS) waa daawada afka ee firfircoon ee Dabigatran. Dabigatran etexilate mesylate waxay leedahay saameyn liddi ku ah xinjirowga lidka ku ah waxaana loo isticmaalaa kahortagga xididdada dhiig-karka iyo istaroogga oo ay ugu wacan tahay fibrillada atrial.
Asalkii hore
Sharaxaad: IC50 Qiimaha: 4.5nM (Ki); 10nm in vitro: Dabigatran si xulashada iyo dib-u-noqoshada ah ayaa xannibay thrombin bini'aadamka (Ki: 4.5 nM) iyo sidoo kale isku-darka trombobin-induced platelet (IC(50): 10 nM), iyadoo aan muujineynin wax saameyn ah oo ku saabsan wakiilada kale ee kicinta platelet. Jiilka Thrombin ee platelet. Plasma liidata (PPP), oo lagu cabiray awooda thrombin endogenous (ETP) ayaa la joojiyay. fiirsashada-ku-tiirsanaanta (IC(50): 0.56 microM). Dabigatran waxay muujisay saamaynta xinjirowga lidka ku-tiirsan ee noocyada kala duwan ee vitro, taasoo labanlaabaysa qayb firfircoon oo thromboplastin ah (aPTT), wakhtiga prothrombin (PT) iyo wakhtiga xinjirowga ecarin (ECT) ee PPP ee bini'aadamka ee 0.23, 0.83 iyo 0.18 microM, siday u kala horreeyaan. 1]. gudaha Vivo: Dabigatran waxay dheeraysay qiyaasta aPTT-ku-tiirsanaanta ka dib maamulka xididada ee jiirka (0.3, 1 iyo 3 mg/kg) iyo daanyeerka rhesus (0.15, 0.3 iyo 0.6 mg/kg). Saamaynta xinjirowga lidka ku ah qiyaasta iyo waqtiga-ku-tiirsanaanta ayaa lagu arkay dabigatran etexilate oo afka laga maamulo jiirka miyirka leh (10, 20 iyo 50 mg/kg) ama daayeerrada rhesus (1, 2.5 ama 5 mg/kg), oo leh saamaynta ugu badan ee lagu arkay inta u dhaxaysa 30 iyo 120 min ka dib maamulka, siday u kala horreeyaan [1]. Bukaannada lagu daweeyay dabigatran etexilate waxay la kulmeen ischaemic ischemic oo yar (3.74 dabigatran etexilate vs 3.97 warfarin) iyo in yar oo isku darka dhiigbaxa intracranial iyo dhiigbaxa dhiigbaxa (0.43 dabigatran etexilate vs 0.99 warfarin) 1020 bukaan ah. Tijaabada caafimaad: Qiimaynta Farmacokinetics iyo Pharmacodynamics ee Dabigatran Etexilate Oral ee Bukaannada Hemodialysis. Wajiga 1aad
Kaydinta
| Budada | -20°C | 3 sano |
| 4°C | 2 sano | |
| Ku milmay | -80°C | 6 bilood |
| -20°C | 1 bil |
Tijaabo Caafimaad
| Lambarka NCT | Kafiil | Xaalad | Taariikhda Bilawga | Marxaladda |
| NCT02170792 | Boehringer Ingelheim | Caafimaad qaba | Febraayo 2001 | Wajiga 1 |
| NCT02170974 | Boehringer Ingelheim | Caafimaad qaba | July 2004 | Wajiga 1 |
| NCT02170831 | Boehringer Ingelheim | Caafimaad qaba | May 1999kii | Wajiga 1 |
| NCT02170805 | Boehringer Ingelheim | Caafimaad qaba | Abriil 2001 | Wajiga 1 |
| NCT02170610 | Boehringer Ingelheim | Caafimaad qaba | March 2002 | Wajiga 1 |
| NCT02170909 | Boehringer Ingelheim | Caafimaad qaba | December 2004 | Wajiga 1 |
| NCT02171000 | Boehringer Ingelheim | Caafimaad qaba | Abriil 2005 | Wajiga 1 |
| NCT02170844 | Boehringer Ingelheim | Caafimaad qaba | Juun 2004 | Wajiga 1 |
| NCT02170584 | Boehringer Ingelheim | Caafimaad qaba | Janaayo 2001 | Wajiga 1 |
| NCT02170935 | Boehringer Ingelheim | Dhiig-xinjirow (venous Thromboembolism). | Abriil 2002 | Wajiga 2 |
| NCT02170636 | Boehringer Ingelheim | Caafimaad qaba | Janaayo 2002 | Wajiga 1 |
| NCT02170766 | Boehringer Ingelheim | Caafimaad qaba | Oktoobar 2000 | Wajiga 1 |
| NCT02171442 | Boehringer Ingelheim | Caafimaad qaba | Abriil 2002 | Wajiga 1 |
| NCT02170896 | Boehringer Ingelheim | Caafimaad qaba | Oktoobar 2001 | Wajiga 1 |
| NCT02173730 | Boehringer Ingelheim | Caafimaad qaba | November 2002 | Wajiga 1 |
| NCT02170623 | Boehringer Ingelheim | Caafimaad qaba | Febraayo 2002 | Wajiga 1 |
| NCT02170116 | Boehringer Ingelheim | Caafimaad qaba | November 1998kii | Wajiga 1 |
| NCT02170597 | Boehringer Ingelheim | Caafimaad qaba | Ogosto 2003 | Wajiga 1 |
| NCT01225822 | Boehringer Ingelheim | Dhiig-xinjirow (venous Thromboembolism). | November 2002 | Wajiga 2 |
| NCT02170701 | Boehringer Ingelheim | Dhiig-xinjirow (venous Thromboembolism). | Oktoobar 2000 | Wajiga 2 |
| NCT02170740 | Boehringer Ingelheim | Caafimaad qaba | November 1999kii | Wajiga 1 |
| NCT02170922 | Boehringer Ingelheim | Caafimaad qaba | Luulyo 1999kii | Wajiga 1 |
Qaab dhismeedka kiimikada
Soo jeedin18Mashaariicda Qiimaynta Joogtada Tayada ee la ansixiyay4iyo6mashaariicda ayaa ku socda ansixinta.
Nidaamka maaraynta tayada sare ee caalamiga ah ayaa aasaas adag u dhigay iibka.
Kormeerka tayada wuxuu ku socdaa dhammaan wareegga nolosha ee alaabta si loo hubiyo tayada iyo saameynta daaweynta.
Kooxda Arrimaha Xeer-ilaalinta Xirfadlayaasha waxay taageertaa shuruudaha tayada inta lagu jiro codsiga iyo diiwaangelinta.
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