Asalkii hore

Canagliflozin waa sheeko cusub, awood leh, oo aad u xushay soodhiyam gulukoos wada-qaade (SGLT) 2 inhibitor [1]. Waxaa la caddeeyey in Canagliflozin ay kordhin karto soosaarka gulukooska kaadida iyada oo la dhimayo heerka gulukooska kelyaha iyo iyadoo hoos u dhigaysa dib u nuugista gulukoosta la sifeeyay [2].

Canagliflozin ayaa la muujiyay in ay joojiso qaadashada Na +-dhexdhexaadinta 14C-AMG ee CHO-hSGLT2, CHO-rat SGLT2 iyo CHO-mouse SGLT2 oo leh IC50 qiimaha 4.4, 3.7 iyo 2.0 nM, siday u kala horreeyaan [1].

Canagliflozin ayaa la sheegay inay hoos u dhigto heerarka gulukooska dhiigga (BG) qiyaasta ku tiirsanaanta jiirka db/db iyo dufanka macaan ee Zucker (ZDF) labadaba. Intaa waxaa dheer, canagliflozin waxay cadaysay inay hoos u dhigto saamiga sarrifka neefsiga, iyo miisaanka jidhka ee jiirarka DIO iyo jiirka ZDF [1].

Canagliflozin waxaa laga qaadan karaa afka [1].

Tixraacyo:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Saamaynta canagliflozin ee marinka kelyaha gulukoosta, glycemia, iyo miisaanka jidhka ee noocyada xoolaha caadiga ah iyo kuwa macaanka. PLoS Mid. 2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), Wakiilka Afka Novel ee Nooca-2 ee Sonkorowga. P T. 2013 Nof;38 (11): 656-66

Tixraaca Alaabta

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, iyo al. "Farsamooyinka xallinta kala duwan ee maaraynta spectra is-dul-saaran: Codsiga go'aaminta dawooyinka hypoglycemic-ga cusub ee la sameeyay ee foomka qiyaasta daawada ee la isku daray." Spectrochimica Acta Qaybta A: Molecular iyo Biomolecular Spectroscopy La heli karo onlayn 20ka Juun 2018.

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