Bictegravir 1611493-60-7
Sharaxaada
Bictegravir waa sheeko cusub, horjooge awood leh ee HIV-1 isku-dhafka IC50 ee 7.5 nM.
In Vitro
Bictegravir (BIC) waxay joojisaa dhaqdhaqaaqa wareejinta xadhigga IC50 ee 7.5± 0.3 nM Marka loo eego ka-hortagga dhaqdhaqaaqa wareejinta xargaha, Bictegravir waa horjooge aad u daciif ah oo ah 3"Waxqabadka HIV-1 IN, oo leh IC50 ee 241±51 nM. Bictegravir waxay kor u qaadaysaa ururinta 2-LTR wareegyada ~ 5-laab marka loo eego kantaroolka la daweeyay ee jeesjeeska ah waxayna yaraynaysaa qadarka alaabta isdhexgalka dhabta ah ee unugyada cudurka qaba 100-laab. Bictegravir waxay si xoog leh u joojisaa ku-noqoshada HIV-1 ee labadaba unugyada MT-2 iyo MT-4 ee leh EC50s ee 1.5 iyo 2.4 nM, siday u kala horreeyaan. Bictegravir waxay soo bandhigtaa saameyn xoog leh oo fayruska ka hortagga ah labadaba CD4+ T lymphocytes iyo macrophages monocyte-ka-soo-baxa, oo leh EC50s ee 1.5±0.3 nM iyo 6.6±4.1 nM, siday u kala horreeyaan, kuwaas oo u dhigma qiyamka laga helay xariiqyada T-cell[1].
MCE si madaxbanaan uma aysan xaqiijin saxnaanta hababkan. Waxay yihiin tixraac kaliya.
| Lambarka NCT | Kafiil | Xaalad | Taariikhda Bilawga | Marxaladda |
| NCT03998176 | Jaamacadda Nebraska | Sayniska Gilead | HIV-1-cudurka | Oktoobar 9, 2019 | Wajiga 4 |
| NCT03789968 | Thomas Jefferson University|Jaamacadda Maryland, College Park | Caafimaadka Jaamacadda Indiana | Xarunta Isbitaalka Brooklyn | Jaamacadda Illinois ee Chicago | HIV+AIDS | Sebtember 1, 2019 | |
| NCT04249037 | Jaamacadda Colorado, Denver | Sayniska Gilead | HIV+AIDS | Maarso 1, 2020 | Aan lagu dabaqi karin |
| NCT04132674 | Xarunta cudurada faafa ee Vancouver | Fayraska Immundeficiency Immundeficiency Infection | Isticmaalka Daroogada | November 26, 2018 | Wajiga 4 |
| NCT04054089 | Cristina Mussini | Jaamacadda Modena iyo Reggio Emilia | Caabuqa HIV | Sebtembar 2019 | Wajiga 4 |
| NCT04155554 | Azienda Ospedaliera Universitaria Senese|Jaamacadda Katooliga ee Qalbiga Xurmada leh|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia | HIV-1-cudurka | Janaayo 29, 2020 | Wajiga 3 |
| NCT02275065 | Sayniska Gilecaad | Caabuqa HIV-1 | Oktoobar 2014 | Wajiga 1 |
| NCT03711253 | Jaamacadda Koonfurta California | Caabuqa HIV Ba'an | Oktoobar 14, 2019 | Wajiga 4 |
| NCT02400307 | Sayniska Gilecaad | HIV | Abriil 17, 2015 | Wajiga 1 |
| NCT03499483 | Caafimaadka Bulshada Fenway | Kahortagga HIV | Janaayo 24, 2019 | Wajiga 4 |
| NCT03502005 | Kooxda Cilmi-baarista Midland, Inc. | Sayniska Gilead | Fayraska difaaca jirka aadanaha | Maarso 1, 2018 | Wajiga 4 |
Qaab dhismeedka kiimikada
Soo jeedin18Mashaariicda Qiimaynta Joogtada Tayada ee la ansixiyay4iyo6mashaariicda ayaa ku socda ansixinta.
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