Asalkii hore

Calcium Atorvastatin waa horjooge awood leh oo HMG-CoA reductase leh IC50 oo qiimaheedu yahay 150 nM.
HMG-CoA reductase waa enzyme muhiimka ah ee dariiqa mevalonate kaas oo soo saara kolestaroolka.HMG-CoA waa enzyme xaddidaya heerka waxayna muhiim u tahay hoos u dhigista heerarka kolestaroolka dhiigga.HMG-CoA reductase waxa uu ku yaalaa xuubka endoplasmic reticulum waxana uu ka kooban yahay sideed qaybood oo transmembrane ah.Ka-hortagga HMG-CoA reductase waxay kicin karaan LDL (lipoprotein cufnaanta hoose) ee soo-dhoweynta beerka.Waxay keenaysaa in la kordhiyo heerka catabolism ee plasma LDL iyo hoos u fiirsashada ee kolestaroolka balasmaha taas oo muhiim u ah go'aaminta atherosclerosis.HMG-CoA reductase waxay door muhiim ah ka ciyaartaa isku dhafka kolestaroolka.HMG-CoA waa bartilmaameedka kaliya ee daawooyinka hoos u dhiga kolestaroolka.HMG-CoA reductase sidoo kale waa enzyme muhiim u ah horumarka.Hawsha HMG-CoA reductase waxay la xiriirtaa cilladaha socdaalka unugga jeermiska.Joojinta hawsheeda waxay u horseedi kartaa dhiig-baxa maskaxda [1].
Atorvastatin waa HMG-CoA reductase inhibitor oo leh IC50 oo qiimaheedu yahay 154 nM.Waxay wax ku ool u tahay daaweynta dyslipidemias qaarkood iyo hypercholesterolemia[1].Daawaynta Atorvastatin ee 40 mg waxay hoos u dhigtaa wadarta kolestaroolka 40% 40 maalmood kadib.[1]Waxa kale oo loo isticmaalaa in lagu daweeyo bukaannada halbowlayaasha ama istaroogga leh heerarka kolestaroolka caadiga ah.[2]Atorvastatin waxay sidoo kale hoos u dhigtaa apheresis lipoprotein cufnaanta hoose ee bukaanka iyadoo kicinaysa muujinta LDL-receptors.
Waxaa la dheefshiido dhowr dheef-shiid kiimikaad kuwaas oo muhiim u ah saameynta ficillada daweynta ee CYP3A4 (cytochrome P450 3A4).[3]
Tixraacyo:
[1]van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ.Wadnaha 2002, 88 (3): 234-238.
[2].Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al. -celcelis ahaan uruurinta kolestaroolka, gudaha Anglo-Scandinavian Natiijooyinka Wadnaha Tijaabada -- Cududda Hooseysa ee Lipid (ASCOT-LLA): tijaabo la kantaroolo oo kala duwan oo xarumo badan ah.Lancet 2003, 361 (9364): 1149-1158.
[3]Lennernas H: Farmashiyaha kiliinikada ee atorvastatin.Clin Pharmacokinet 2003, 42 (13): 1141-1160.

Qaab dhismeedka kiimikada