Asalkii hore

Calcium Atorvastatin waa horjooge awood leh oo HMG-CoA reductase leh IC50 oo qiimaheedu yahay 150 nM[1].
HMG-CoA reductase waa enzyme muhiimka ah ee dariiqa mevalonate kaas oo soo saara kolestaroolka. HMG-CoA waa enzyme xaddidaya heerka xaddidaadda waxayna muhiim u tahay hoos u dhigista heerarka kolestaroolka dhiigga. HMG-CoA reductase waxay ku taalaa xuubka endoplasmic reticulum wuxuuna ka kooban yahay sideed qaybood oo transmembrane ah. Ka-hortagga HMG-CoA reductase waxay kicin karaan LDL (lipoprotein cufnaanta hoose) ee soo-dhoweynta beerka. Waxay keenaysaa in la kordhiyo heerka catabolism ee plasma LDL iyo hoos u fiirsashada ee kolestaroolka balasmaha taas oo ah go'aami muhiim ah atherosclerosis. HMG-CoA reductase waxay door muhiim ah ka ciyaartaa isku dhafka kolestaroolka. HMG-CoA waa bartilmaameedka kaliya ee daawooyinka hoos u dhigaya kolestaroolka. HMG-CoA reductase sidoo kale waa enzyme muhiim u ah horumarka. Hawsha HMG-CoA reductase waxay la xiriirtaa cilladaha socdaalka unugyada jeermiska. Joojinta hawsheeda waxay u horseedi kartaa dhiig-baxa maskaxda [1].
Atorvastatin waa HMG-CoA reductase inhibitor oo leh IC50 oo qiimaheedu yahay 154 nM. Waxay wax ku ool u tahay daaweynta dyslipidemias qaarkood iyo hypercholesterolemia[1]. Daawaynta Atorvastatin ee 40 mg waxay hoos u dhigtaa wadarta kolestaroolka 40% 40 maalmood ka dib.[1] Waxa kale oo loo isticmaalaa in lagu daweeyo bukaannada halbowlayaasha ama istaroogga leh heerarka kolestaroolka caadiga ah.[2] Atorvastatin waxay sidoo kale hoos u dhigtaa apheresis lipoprotein cufnaanta hoose ee bukaanka iyadoo kicinaysa muujinta LDL-receptors.
Waxaa la dheefshiido dhowr metabolites kuwaas oo muhiim u ah saameynta ficillada daweynta ee CYP3A4 (cytochrome P450 3A4).[3]
Tixraacyo:
[1] van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Waxtarka muddada dheer iyo badbaadada atorvastatin ee daaweynta nooca daran ee III iyo isku-darka dyslipidemia. Wadnaha 2002, 88 (3): 234-238.
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al. -celcelis ahaan uruurinta kolestaroolka, gudaha Anglo-Scandinavian Natiijooyinka Wadnaha Tijaabada -- Hoos u dhigista gacanta. (ASCOT-LLA): waa tijaabo kontorool oo aan kala sooc lahayn oo xarunteedu badan tahay. Lancet 2003, 361(9364):1149-1158.
[3] Lennernas H: Farmashiyaha kiliinikada ee atorvastatin. Clin Pharmacokinet 2003, 42 (13): 1141-1160.

Qaab dhismeedka kiimikada